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• W2764085364 abstract "The NLRC3-like (NLRC3L) molecule from the goldfish transcriptome database was identified and characterized. Quantitative gene expression analysis revealed the highest mRNA levels of NLRC3L were in the spleen and intestine, with lower mRNA levels observed in muscle and liver. Goldfish NLRC3L was differentially expressed in goldfish immune cell populations with highest mRNA levels measured in PBLs and macrophages. We generated a recombinant form of the molecule (rgfNLRC3L) and an anti-CT-NLRC3L IgG. Treatment of goldfish primary kidney macrophages in vitro with ATP, LPS and heat-killed Aeromonas salmonicida up-regulated the NLRC3L mRNA and protein. Confocal microscopy and co-immunoprecipitation assays indicated that goldfish rgfNLRC3L interacted with apoptosis-associated spec-like protein (ASC) in eukaryotic cells, indicating that NLRC3L may participate in the regulation of the inflammasome responses. The dual-luciferase reporter assay showed that NLRC3L over-expression did not cause the activation of NF-κB, but that it cooperated with RIP2 to down-regulate NF-κB activation. Our results indicate that the NLRC3L may function as a regulator of NLR pathways in teleosts." @default.
• W2764085364 created "2017-10-20" @default.
• W2764085364 creator A5016741447 @default.
• W2764085364 creator A5068803307 @default.
• W2764085364 date "2018-02-01" @default.
• W2764085364 modified "2023-10-17" @default.
• W2764085364 title "Characterization and functional assessment of the NLRC3-like molecule of the goldfish (Carassius auratus L.)" @default.
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• W2764085364 doi "https://doi.org/10.1016/j.dci.2017.09.021" @default.
• W2764085364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28988993" @default.
• W2764085364 hasPublicationYear "2018" @default.
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