FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764111246> ?p ?o ?g. }

• W2764111246 endingPage "154" @default.
• W2764111246 startingPage "143" @default.
• W2764111246 abstract "In this report, the solubilization behaviour of a hydrophobic drug Clozapine (CLZ) in micellar suspensions of pluronics having different hydrophilic lipophilic balance (HLB) ratios viz. P84, F127 and F108 in the absence and presence of bile salt sodium deoxycholate (SDC) has been studied. UV–Vis spectroscopy has been exploited to determine the solubilization capacity of the investigated micellar systems in terms of drug loading efficiency, average number of drug molecules solubilized per micelle (ns), partition coefficient (P) and standard free energy of solubilization (∆ G°). The morphological and structural changes taking place in pluronics in different concentration regimes of SDC and with the addition of drug CLZ has been explored using dynamic light scattering (DLS) and small angle neutron scattering (SANS) measurements. The SANS results revealed that aggregation behaviour of pluronic-SDC mixed micelles gets improved in the presence of drug. The micropolarity measurements have been performed to shed light on the locus of solubilization of the drug in pure and mixed micellar systems. The compatibility between CLZ and drug carriers (pluronics and SDC) was confirmed using powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR) techniques. Among the investigated systems, P84-SDC mixed system was found to be highly efficient for CLZ loading. The long term stability data indicated that CLZ loaded P84-SDC mixed micellar formulation remained stable for 3 months at room temperature. Further, it was revealed that the CLZ loaded P84-SDC mixed micelles are converted into CLZ loaded pure P84 micelles at 30-fold dilutions which remain stable up to 48-fold dilutions. The results from the present studies suggest that P84-SDC mixed micelles can serve as suitable delivery vehicles for hydrophobic drug CLZ." @default.
• W2764111246 created "2017-10-20" @default.
• W2764111246 creator A5008359936 @default.
• W2764111246 creator A5034352121 @default.
• W2764111246 creator A5041540712 @default.
• W2764111246 creator A5076424230 @default.
• W2764111246 creator A5083770323 @default.
• W2764111246 date "2018-02-01" @default.
• W2764111246 modified "2023-10-16" @default.
• W2764111246 title "Sodium deoxycholate mediated enhanced solubilization and stability of hydrophobic drug Clozapine in pluronic micelles" @default.
• W2764111246 cites W1662084969 @default.
• W2764111246 cites W1770563882 @default.
• W2764111246 cites W1930057874 @default.
• W2764111246 cites W1964026121 @default.
• W2764111246 cites W1968688544 @default.
• W2764111246 cites W1968937518 @default.
• W2764111246 cites W1978466251 @default.
• W2764111246 cites W1980788926 @default.
• W2764111246 cites W1993053769 @default.
• W2764111246 cites W1993948196 @default.
• W2764111246 cites W1994042312 @default.
• W2764111246 cites W1996288050 @default.
• W2764111246 cites W1997742053 @default.
• W2764111246 cites W2000086329 @default.
• W2764111246 cites W2000136129 @default.
• W2764111246 cites W2012427136 @default.
• W2764111246 cites W2020800586 @default.
• W2764111246 cites W2023285102 @default.
• W2764111246 cites W2025285304 @default.
• W2764111246 cites W2029677759 @default.
• W2764111246 cites W2031305612 @default.
• W2764111246 cites W2032736574 @default.
• W2764111246 cites W2034858836 @default.
• W2764111246 cites W2036459378 @default.
• W2764111246 cites W2037790246 @default.
• W2764111246 cites W2037951704 @default.
• W2764111246 cites W2045268151 @default.
• W2764111246 cites W2058652181 @default.
• W2764111246 cites W2060442024 @default.
• W2764111246 cites W2073334259 @default.
• W2764111246 cites W2075440102 @default.
• W2764111246 cites W2076663214 @default.
• W2764111246 cites W2082449380 @default.
• W2764111246 cites W2083990409 @default.
• W2764111246 cites W2084250773 @default.
• W2764111246 cites W2104717900 @default.
• W2764111246 cites W2114095008 @default.
• W2764111246 cites W2123281870 @default.
• W2764111246 cites W2135245979 @default.
• W2764111246 cites W2136472480 @default.
• W2764111246 cites W2140853541 @default.
• W2764111246 cites W2141025633 @default.
• W2764111246 cites W2151763843 @default.
• W2764111246 cites W2153691074 @default.
• W2764111246 cites W2155630620 @default.
• W2764111246 cites W2157007129 @default.
• W2764111246 cites W2226799165 @default.
• W2764111246 cites W2226830739 @default.
• W2764111246 cites W2256300625 @default.
• W2764111246 cites W2281089955 @default.
• W2764111246 cites W2315590170 @default.
• W2764111246 cites W2320415210 @default.
• W2764111246 cites W2330140561 @default.
• W2764111246 cites W2332835628 @default.
• W2764111246 cites W2399412628 @default.
• W2764111246 cites W2415826661 @default.
• W2764111246 cites W2518695734 @default.
• W2764111246 doi "https://doi.org/10.1016/j.saa.2017.10.015" @default.
• W2764111246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29028506" @default.
• W2764111246 hasPublicationYear "2018" @default.
• W2764111246 type Work @default.
• W2764111246 sameAs 2764111246 @default.
• W2764111246 citedByCount "40" @default.
• W2764111246 countsByYear W27641112462018 @default.
• W2764111246 countsByYear W27641112462019 @default.
• W2764111246 countsByYear W27641112462020 @default.
• W2764111246 countsByYear W27641112462021 @default.
• W2764111246 countsByYear W27641112462022 @default.
• W2764111246 countsByYear W27641112462023 @default.
• W2764111246 crossrefType "journal-article" @default.
• W2764111246 hasAuthorship W2764111246A5008359936 @default.
• W2764111246 hasAuthorship W2764111246A5034352121 @default.
• W2764111246 hasAuthorship W2764111246A5041540712 @default.
• W2764111246 hasAuthorship W2764111246A5076424230 @default.
• W2764111246 hasAuthorship W2764111246A5083770323 @default.
• W2764111246 hasConcept C101335993 @default.
• W2764111246 hasConcept C11268172 @default.
• W2764111246 hasConcept C127413603 @default.
• W2764111246 hasConcept C13965031 @default.
• W2764111246 hasConcept C14631669 @default.
• W2764111246 hasConcept C155672457 @default.
• W2764111246 hasConcept C15920480 @default.
• W2764111246 hasConcept C160892712 @default.
• W2764111246 hasConcept C171250308 @default.
• W2764111246 hasConcept C178790620 @default.
• W2764111246 hasConcept C184651966 @default.
• W2764111246 hasConcept C185592680 @default.
• W2764111246 hasConcept C192562407 @default.

• next