Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764114101> ?p ?o ?g. }
- W2764114101 abstract "Highlights The Drosophila BBB displays a circadian rhythm of permeability Cyclic efflux driven by a clock in the BBB underlies the permeability rhythm Circadian control is non-cell-autonomous via gap junction regulation of [Mg 2+ ]i An anti-seizure drug is more effective when administered at night Summary Endogenous circadian rhythms are thought to modulate responses to external factors, but mechanisms that confer time-of-day differences in organismal responses to environmental insults / therapeutic treatments are poorly understood. Using a xenobiotic, we find that permeability of the Drosophila “blood”-brain barrier (BBB) is higher at night. The permeability rhythm is driven by circadian regulation of efflux and depends upon a molecular clock in the perineurial glia of the BBB, although efflux transporters are restricted to subperineurial glia (SPG). We show that transmission of circadian signals across the layers requires gap junctions, which are expressed cyclically. Specifically, during nighttime gap junctions reduce intracellular magnesium ([Mg 2+ ]i), a positive regulator of efflux, in SPG. Consistent with lower nighttime efflux, nighttime administration of the anti-epileptic phenytoin is more effective at treating a Drosophila seizure model. These findings identify a novel mechanism of circadian regulation and have therapeutic implications for drugs targeted to the central nervous system." @default.
- W2764114101 created "2017-10-20" @default.
- W2764114101 creator A5000646345 @default.
- W2764114101 creator A5002976445 @default.
- W2764114101 creator A5062817134 @default.
- W2764114101 creator A5073845843 @default.
- W2764114101 date "2017-10-04" @default.
- W2764114101 modified "2023-09-30" @default.
- W2764114101 title "A circadian clock in the blood-brain barrier regulates xenobiotic efflux from the brain" @default.
- W2764114101 cites W128151115 @default.
- W2764114101 cites W1921252690 @default.
- W2764114101 cites W1965522214 @default.
- W2764114101 cites W1977447552 @default.
- W2764114101 cites W1978983065 @default.
- W2764114101 cites W1984673374 @default.
- W2764114101 cites W1985723872 @default.
- W2764114101 cites W1986657180 @default.
- W2764114101 cites W1995139743 @default.
- W2764114101 cites W1997148899 @default.
- W2764114101 cites W1997576057 @default.
- W2764114101 cites W1998340140 @default.
- W2764114101 cites W1999476407 @default.
- W2764114101 cites W2002425839 @default.
- W2764114101 cites W2007299852 @default.
- W2764114101 cites W2008487250 @default.
- W2764114101 cites W2011646214 @default.
- W2764114101 cites W2013075448 @default.
- W2764114101 cites W2053069467 @default.
- W2764114101 cites W2055646225 @default.
- W2764114101 cites W2056395995 @default.
- W2764114101 cites W2062988834 @default.
- W2764114101 cites W2077328898 @default.
- W2764114101 cites W2088910052 @default.
- W2764114101 cites W2092550544 @default.
- W2764114101 cites W2094571184 @default.
- W2764114101 cites W2111943141 @default.
- W2764114101 cites W2113153454 @default.
- W2764114101 cites W2115370894 @default.
- W2764114101 cites W2121321456 @default.
- W2764114101 cites W2132687554 @default.
- W2764114101 cites W2135843883 @default.
- W2764114101 cites W2143311793 @default.
- W2764114101 cites W2151494919 @default.
- W2764114101 cites W2154401636 @default.
- W2764114101 cites W2161356018 @default.
- W2764114101 cites W2163225965 @default.
- W2764114101 cites W2164824098 @default.
- W2764114101 cites W2253028130 @default.
- W2764114101 cites W2333798941 @default.
- W2764114101 cites W2337498788 @default.
- W2764114101 cites W2340896227 @default.
- W2764114101 cites W2400870314 @default.
- W2764114101 cites W2505939472 @default.
- W2764114101 cites W2592834736 @default.
- W2764114101 cites W2603862537 @default.
- W2764114101 cites W2617723761 @default.
- W2764114101 cites W30813508 @default.
- W2764114101 doi "https://doi.org/10.1101/196956" @default.
- W2764114101 hasPublicationYear "2017" @default.
- W2764114101 type Work @default.
- W2764114101 sameAs 2764114101 @default.
- W2764114101 citedByCount "0" @default.
- W2764114101 crossrefType "posted-content" @default.
- W2764114101 hasAuthorship W2764114101A5000646345 @default.
- W2764114101 hasAuthorship W2764114101A5002976445 @default.
- W2764114101 hasAuthorship W2764114101A5062817134 @default.
- W2764114101 hasAuthorship W2764114101A5073845843 @default.
- W2764114101 hasBestOaLocation W27641141011 @default.
- W2764114101 hasConcept C115448650 @default.
- W2764114101 hasConcept C121446783 @default.
- W2764114101 hasConcept C134018914 @default.
- W2764114101 hasConcept C16613235 @default.
- W2764114101 hasConcept C169760540 @default.
- W2764114101 hasConcept C181199279 @default.
- W2764114101 hasConcept C200082930 @default.
- W2764114101 hasConcept C2778402981 @default.
- W2764114101 hasConcept C38606739 @default.
- W2764114101 hasConcept C529278444 @default.
- W2764114101 hasConcept C55493867 @default.
- W2764114101 hasConcept C86803240 @default.
- W2764114101 hasConcept C95444343 @default.
- W2764114101 hasConceptScore W2764114101C115448650 @default.
- W2764114101 hasConceptScore W2764114101C121446783 @default.
- W2764114101 hasConceptScore W2764114101C134018914 @default.
- W2764114101 hasConceptScore W2764114101C16613235 @default.
- W2764114101 hasConceptScore W2764114101C169760540 @default.
- W2764114101 hasConceptScore W2764114101C181199279 @default.
- W2764114101 hasConceptScore W2764114101C200082930 @default.
- W2764114101 hasConceptScore W2764114101C2778402981 @default.
- W2764114101 hasConceptScore W2764114101C38606739 @default.
- W2764114101 hasConceptScore W2764114101C529278444 @default.
- W2764114101 hasConceptScore W2764114101C55493867 @default.
- W2764114101 hasConceptScore W2764114101C86803240 @default.
- W2764114101 hasConceptScore W2764114101C95444343 @default.
- W2764114101 hasLocation W27641141011 @default.
- W2764114101 hasLocation W27641141012 @default.
- W2764114101 hasOpenAccess W2764114101 @default.
- W2764114101 hasPrimaryLocation W27641141011 @default.
- W2764114101 hasRelatedWork W1451660723 @default.
- W2764114101 hasRelatedWork W1791717493 @default.