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- W2764131057 abstract "Resolution of viral infections requires activation of innate cells to initiate and maintain adaptive immune responses. In this study, we examined Japanese encephalitis virus (JEV) infection leading to acute encephalopathy depending on suppression of the adaptive immune responses mediated by innate cells. Infection with P3 strains of JEV enhanced myeloid-derived suppressor cell (MDSC) populations, and the survival rate of JEV-infected mice improved after MDSC depletion. Mechanically, P3-induced MDSCs suppressed CD4+ T cell immune responses, especially responses of T follicular helper (Tfh) cells, leading to decreased splenic B cells (CD19+) and blood plasma cells (CD19+CD138+) and reduced levels of total IgM and JEV-specific neutralizing Abs. Upon depleting P3-induced MDSCs in vivo, the Tfh cell population, B cells, plasma cells, and Ab production recovered. These findings provide unique insights regarding MDSC functions in mediating immune suppression via inhibiting Tfh cell responses and further impairing humoral immunity, which facilitate the progression of infection." @default.
- W2764131057 created "2017-10-20" @default.
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- W2764131057 date "2017-11-01" @default.
- W2764131057 modified "2023-10-16" @default.
- W2764131057 title "Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection" @default.
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- W2764131057 cites W2155327161 @default.
- W2764131057 cites W2156094245 @default.
- W2764131057 cites W2156915900 @default.
- W2764131057 cites W2163825883 @default.
- W2764131057 cites W2168949615 @default.
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- W2764131057 doi "https://doi.org/10.4049/jimmunol.1700671" @default.
- W2764131057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28978693" @default.
- W2764131057 hasPublicationYear "2017" @default.
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