Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764134495> ?p ?o ?g. }
- W2764134495 endingPage "282" @default.
- W2764134495 startingPage "277" @default.
- W2764134495 abstract "Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is recognized to be a potent innate inflammatory mediator that can activate the nuclear factor light chain enhancer of activated B cells and release cytokines such as IL-6 and IL-17A when released extracellularly. However, whether cerebrospinal fluid (CSF) HMGB1 levels are altered in anti-NMDAR encephalitis is still unclear. Objective The aim of this study was to determine whether a correlation exists between the CSF concentrations of HMGB1 and IL-6 and IL-17A in anti-NMDAR encephalitis patients. We also sought to assess whether HMGB1 influences the clinical outcomes in anti-NMDAR encephalitis patients. Methods Thirty-three patients with anti-NMDAR antibodies and 38 controls were recruited. CSF HMGB1 was measured using an enzyme-linked immunosorbent assay. The main clinical outcomes were evaluated using the modified Rankin scale (mRS). The data were extracted using microarray analysis software. Results and Conclusion Our results showed significant increases in CSF HMGB1, IL-6, and IL-17A (P < .05) in anti-NMDAR encephalitis patients. But between 3 months’ mRS scores in anti-NMDAR encephalitis patients and CSF data, there was no correlation. Our study suggests that HMGB1 CSF levels are increased in patients with anti-NMDAR encephalitis and reflect the underlying neuroinflammatory process." @default.
- W2764134495 created "2017-10-20" @default.
- W2764134495 creator A5018853632 @default.
- W2764134495 creator A5025441749 @default.
- W2764134495 creator A5031755601 @default.
- W2764134495 creator A5037086767 @default.
- W2764134495 creator A5056664727 @default.
- W2764134495 creator A5072687782 @default.
- W2764134495 creator A5090176252 @default.
- W2764134495 date "2017-10-12" @default.
- W2764134495 modified "2023-10-18" @default.
- W2764134495 title "The <scp>HMGB</scp> 1 is increased in <scp>CSF</scp> of patients with an Anti‐ <scp>NMDAR</scp> encephalitis" @default.
- W2764134495 cites W1896731228 @default.
- W2764134495 cites W1921385723 @default.
- W2764134495 cites W1984957231 @default.
- W2764134495 cites W1989513568 @default.
- W2764134495 cites W2013576325 @default.
- W2764134495 cites W2018894105 @default.
- W2764134495 cites W2026428131 @default.
- W2764134495 cites W2028195000 @default.
- W2764134495 cites W2031188093 @default.
- W2764134495 cites W2031558790 @default.
- W2764134495 cites W2033905745 @default.
- W2764134495 cites W2035462578 @default.
- W2764134495 cites W2038063394 @default.
- W2764134495 cites W2051552021 @default.
- W2764134495 cites W2059718338 @default.
- W2764134495 cites W2061163173 @default.
- W2764134495 cites W2069821412 @default.
- W2764134495 cites W2070769098 @default.
- W2764134495 cites W2072597173 @default.
- W2764134495 cites W2086539844 @default.
- W2764134495 cites W2092372960 @default.
- W2764134495 cites W2096069651 @default.
- W2764134495 cites W2114398221 @default.
- W2764134495 cites W2114445825 @default.
- W2764134495 cites W2130775443 @default.
- W2764134495 cites W2150806631 @default.
- W2764134495 cites W2160427694 @default.
- W2764134495 cites W2163022996 @default.
- W2764134495 cites W2163314276 @default.
- W2764134495 cites W2164714222 @default.
- W2764134495 cites W2165380579 @default.
- W2764134495 cites W2168677679 @default.
- W2764134495 cites W2280783985 @default.
- W2764134495 cites W2410553907 @default.
- W2764134495 cites W2441449165 @default.
- W2764134495 cites W4211173052 @default.
- W2764134495 doi "https://doi.org/10.1111/ane.12850" @default.
- W2764134495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29023630" @default.
- W2764134495 hasPublicationYear "2017" @default.
- W2764134495 type Work @default.
- W2764134495 sameAs 2764134495 @default.
- W2764134495 citedByCount "19" @default.
- W2764134495 countsByYear W27641344952018 @default.
- W2764134495 countsByYear W27641344952019 @default.
- W2764134495 countsByYear W27641344952020 @default.
- W2764134495 countsByYear W27641344952021 @default.
- W2764134495 countsByYear W27641344952022 @default.
- W2764134495 countsByYear W27641344952023 @default.
- W2764134495 crossrefType "journal-article" @default.
- W2764134495 hasAuthorship W2764134495A5018853632 @default.
- W2764134495 hasAuthorship W2764134495A5025441749 @default.
- W2764134495 hasAuthorship W2764134495A5031755601 @default.
- W2764134495 hasAuthorship W2764134495A5037086767 @default.
- W2764134495 hasAuthorship W2764134495A5056664727 @default.
- W2764134495 hasAuthorship W2764134495A5072687782 @default.
- W2764134495 hasAuthorship W2764134495A5090176252 @default.
- W2764134495 hasBestOaLocation W27641344951 @default.
- W2764134495 hasConcept C126322002 @default.
- W2764134495 hasConcept C203014093 @default.
- W2764134495 hasConcept C2522874641 @default.
- W2764134495 hasConcept C2776914184 @default.
- W2764134495 hasConcept C2778690821 @default.
- W2764134495 hasConcept C2779651940 @default.
- W2764134495 hasConcept C2780545709 @default.
- W2764134495 hasConcept C2780942790 @default.
- W2764134495 hasConcept C2781460105 @default.
- W2764134495 hasConcept C71924100 @default.
- W2764134495 hasConcept C74172505 @default.
- W2764134495 hasConcept C83455156 @default.
- W2764134495 hasConceptScore W2764134495C126322002 @default.
- W2764134495 hasConceptScore W2764134495C203014093 @default.
- W2764134495 hasConceptScore W2764134495C2522874641 @default.
- W2764134495 hasConceptScore W2764134495C2776914184 @default.
- W2764134495 hasConceptScore W2764134495C2778690821 @default.
- W2764134495 hasConceptScore W2764134495C2779651940 @default.
- W2764134495 hasConceptScore W2764134495C2780545709 @default.
- W2764134495 hasConceptScore W2764134495C2780942790 @default.
- W2764134495 hasConceptScore W2764134495C2781460105 @default.
- W2764134495 hasConceptScore W2764134495C71924100 @default.
- W2764134495 hasConceptScore W2764134495C74172505 @default.
- W2764134495 hasConceptScore W2764134495C83455156 @default.
- W2764134495 hasFunder F4320321001 @default.
- W2764134495 hasFunder F4320324202 @default.
- W2764134495 hasIssue "2" @default.
- W2764134495 hasLocation W27641344951 @default.
- W2764134495 hasLocation W27641344952 @default.