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• W2764151189 abstract "A resurgence of mumps was noted recently and outbreaks were increasingly reported in populations with high vaccine coverage. We aimed to evaluate the seroprevalence to mumps in Taiwan, where a two-dose childhood mumps-containing vaccine program, with a high coverage rate, had been implemented for >20 years. The anti-mumps IgG was determined in 3552 participants of all ages in Taiwan. The age-specific seropositivity rates were calculated and the sociodemographic variables associated with the seronegative sera were analyzed with a logistic regression method. The overall seroprevalence to mumps was 71%, with a higher rate in adults ≥19 years old than in the pediatric population <19 years old (80.4% versus 62.0%, P < 0.0001). In participants aged 2–20 years, who had been given at least one mumps-containing vaccine, the seropositivity fluctuated across different age subgroups and the lowest rate (36.8%) occurred in the 17–18 years age group. The multivariate analysis identified age within 17–18 years (adjusted odds ratio [aOR] 8.598, 95% confidence interval [CI] 2.990–24.722, P < 0.0001), within 19–20 years (aOR 5.076, 95% CI 1.702–15.133, P = 0.0080), and being a resident of the suburban area of northern Taiwan (aOR 1.089, 95% CI 0.823–1.414, P = 0.0008) as independent factors associated with an increased risk of seronegative sera. The seropositivity to mumps was unexpectedly low in highly vaccinated generations, and with a significant geographical discrepancy in Taiwan, which may have been responsible for the sustained reports of mumps cases in Taiwan." @default.
• W2764151189 created "2017-10-20" @default.
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• W2764151189 date "2019-06-01" @default.
• W2764151189 modified "2023-09-27" @default.
• W2764151189 title "Humoral immunity to mumps in a highly vaccinated population in Taiwan" @default.
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• W2764151189 doi "https://doi.org/10.1016/j.jmii.2017.09.001" @default.
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