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- W2764199547 abstract "The coronary circulation supplies oxygen to the myocardium. Perfusion of the coronaries happens mainly during diastole. The myocardial blood flow is primarily determined by the perfusion pressure and coronary vascular resistance. The blood flow in the myocardium is closely related to the metabolic activity of the heart muscle and depends on several heterogeneous regulatory mechanisms. Autoregulation of the coronary blood flow, which refers to the ability of the heart to maintain a constant blood flow when the perfusion (driving) pressure changes, as well as tissue metabolites, ions, and endothelial derivatives (such as adenosine, nitric oxide, and potassium), are cardinal mechanisms of flow regulation in the coronaries. Hypoxia and changes of the autonomic nervous system also contribute to keep the oxygen supply/demand balance. Some of these complex pathophysiological and hemodynamic processes, their contribution to normal blood flow, and alterations in coronary stenosis/ischemia are discussed in this chapter." @default.
- W2764199547 created "2017-10-20" @default.
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- W2764199547 date "2018-01-01" @default.
- W2764199547 modified "2023-09-22" @default.
- W2764199547 title "Regulation of Oxygen Transport and Coronary Blood Flow" @default.
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- W2764199547 doi "https://doi.org/10.1016/b978-0-12-811908-2.00010-6" @default.
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