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• W2764271507 abstract "Screening with mammography has been found to increase breast cancer survival rates by about 20%. However, the current system in which mammography is used to direct patients toward biopsy or surgical excision also results in relatively high rates of unnecessary biopsy, as 66.8% of biopsies are benign. A non-ionizing radiation imaging approach with increased specificity might reduce the rate of unnecessary biopsies. Quantifying the vascular characteristics within and surrounding lesions represents one potential target for assessing likelihood of malignancy via imaging. In this clinical note, we describe the translation of a contrast-enhanced ultrasound technique, acoustic angiography, to human imaging. We illustrate the feasibility of this technique with initial studies in imaging the hand, wrist and breast using Definity microbubble contrast agent and a mechanically steered prototype dual-frequency transducer in healthy volunteers. Finally, this approach was used to image pre-biopsy Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 lesions <2 cm in depth in 11 patients. Results indicate that sensitivity and spatial resolution are sufficient to image vessels as small as 0.2 mm in diameter at depths of ~15 mm in the human breast. Challenges observed include motion artifacts, as well as limited depth of field and sensitivity, which could be improved by correction algorithms and improved transducer technologies." @default.
• W2764271507 created "2017-10-20" @default.
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• W2764271507 date "2017-12-01" @default.
• W2764271507 modified "2023-10-15" @default.
• W2764271507 title "First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature" @default.
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• W2764271507 doi "https://doi.org/10.1016/j.ultrasmedbio.2017.08.1881" @default.
• W2764271507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6267932" @default.
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• W2764271507 hasPublicationYear "2017" @default.
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