Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764273516> ?p ?o ?g. }
- W2764273516 endingPage "94634" @default.
- W2764273516 startingPage "94619" @default.
- W2764273516 abstract "Stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 play a critical role in mobilization and redistribution of immune cells and hematopoietic stem cells (HSCs). We evaluated effects of two CXCR4-targeting agents, peptide antagonist LY2510924 and monoclonal antibody LY2624587, on mobilizing HSCs and white blood cells (WBCs) in humans, monkeys, and mice. Biochemical analysis showed LY2510924 peptide blocked SDF-1/CXCR4 binding in all three species; LY2624587 antibody blocked binding in human and monkey, with minimal activity in mouse. Cellular analysis showed LY2624587 antibody, but not LY2510924 peptide, down-regulated cell surface CXCR4 and induced hematological tumor cell death; both agents have been shown to inhibit SDF-1/CXCR4 interaction and downstream signaling. In animal models, LY2510924 peptide induced robust, prolonged, dose- and time-dependent WBC and HSC increases in mice and monkeys, whereas LY2624587 antibody induced only moderate, transient increases in monkeys. In clinical trials, similar pharmacodynamic effects were observed in patients with advanced cancer: LY2510924 peptide induced sustained WBC and HSC increases, while LY2624587 antibody induced only minimal, transient WBC changes. These distinct pharmacodynamic effects in two different classes of CXCR4 inhibitors are clinically important and should be carefully considered when designing combination studies with immune checkpoint inhibitors or other agents for cancer therapy." @default.
- W2764273516 created "2017-10-20" @default.
- W2764273516 creator A5008399936 @default.
- W2764273516 creator A5014574719 @default.
- W2764273516 creator A5027129499 @default.
- W2764273516 creator A5040082320 @default.
- W2764273516 creator A5053675431 @default.
- W2764273516 creator A5053814267 @default.
- W2764273516 creator A5057992918 @default.
- W2764273516 creator A5077342113 @default.
- W2764273516 creator A5088857878 @default.
- W2764273516 creator A5090432805 @default.
- W2764273516 date "2017-10-10" @default.
- W2764273516 modified "2023-09-26" @default.
- W2764273516 title "Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587" @default.
- W2764273516 cites W104449324 @default.
- W2764273516 cites W1487455823 @default.
- W2764273516 cites W1511246213 @default.
- W2764273516 cites W1561964696 @default.
- W2764273516 cites W1602835962 @default.
- W2764273516 cites W1619354717 @default.
- W2764273516 cites W1744174769 @default.
- W2764273516 cites W1930835943 @default.
- W2764273516 cites W1972111686 @default.
- W2764273516 cites W1986986419 @default.
- W2764273516 cites W1994368483 @default.
- W2764273516 cites W1994809546 @default.
- W2764273516 cites W2033577259 @default.
- W2764273516 cites W2035614371 @default.
- W2764273516 cites W2043046186 @default.
- W2764273516 cites W2060070314 @default.
- W2764273516 cites W2067398539 @default.
- W2764273516 cites W2070990188 @default.
- W2764273516 cites W2072785032 @default.
- W2764273516 cites W2080682839 @default.
- W2764273516 cites W2081769332 @default.
- W2764273516 cites W2083612980 @default.
- W2764273516 cites W2085269642 @default.
- W2764273516 cites W2086834665 @default.
- W2764273516 cites W2102089654 @default.
- W2764273516 cites W2102347658 @default.
- W2764273516 cites W2113701976 @default.
- W2764273516 cites W2118083227 @default.
- W2764273516 cites W2120892454 @default.
- W2764273516 cites W2124090816 @default.
- W2764273516 cites W2124514001 @default.
- W2764273516 cites W2125251487 @default.
- W2764273516 cites W2128532174 @default.
- W2764273516 cites W2128645075 @default.
- W2764273516 cites W2139944454 @default.
- W2764273516 cites W2141837666 @default.
- W2764273516 cites W2144456609 @default.
- W2764273516 cites W2150833007 @default.
- W2764273516 cites W2158737833 @default.
- W2764273516 cites W2159812621 @default.
- W2764273516 cites W2159913536 @default.
- W2764273516 cites W2163065691 @default.
- W2764273516 cites W2266192831 @default.
- W2764273516 cites W2295722228 @default.
- W2764273516 cites W4241966903 @default.
- W2764273516 doi "https://doi.org/10.18632/oncotarget.21816" @default.
- W2764273516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5706900" @default.
- W2764273516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29212254" @default.
- W2764273516 hasPublicationYear "2017" @default.
- W2764273516 type Work @default.
- W2764273516 sameAs 2764273516 @default.
- W2764273516 citedByCount "21" @default.
- W2764273516 countsByYear W27642735162018 @default.
- W2764273516 countsByYear W27642735162019 @default.
- W2764273516 countsByYear W27642735162020 @default.
- W2764273516 countsByYear W27642735162021 @default.
- W2764273516 countsByYear W27642735162022 @default.
- W2764273516 countsByYear W27642735162023 @default.
- W2764273516 crossrefType "journal-article" @default.
- W2764273516 hasAuthorship W2764273516A5008399936 @default.
- W2764273516 hasAuthorship W2764273516A5014574719 @default.
- W2764273516 hasAuthorship W2764273516A5027129499 @default.
- W2764273516 hasAuthorship W2764273516A5040082320 @default.
- W2764273516 hasAuthorship W2764273516A5053675431 @default.
- W2764273516 hasAuthorship W2764273516A5053814267 @default.
- W2764273516 hasAuthorship W2764273516A5057992918 @default.
- W2764273516 hasAuthorship W2764273516A5077342113 @default.
- W2764273516 hasAuthorship W2764273516A5088857878 @default.
- W2764273516 hasAuthorship W2764273516A5090432805 @default.
- W2764273516 hasBestOaLocation W27642735161 @default.
- W2764273516 hasConcept C109159458 @default.
- W2764273516 hasConcept C129470790 @default.
- W2764273516 hasConcept C13373296 @default.
- W2764273516 hasConcept C159654299 @default.
- W2764273516 hasConcept C16930146 @default.
- W2764273516 hasConcept C203014093 @default.
- W2764273516 hasConcept C2780492938 @default.
- W2764273516 hasConcept C28328180 @default.
- W2764273516 hasConcept C502942594 @default.
- W2764273516 hasConcept C542903549 @default.
- W2764273516 hasConcept C71924100 @default.
- W2764273516 hasConcept C86803240 @default.
- W2764273516 hasConcept C8891405 @default.