FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764296838> ?p ?o ?g. }

• W2764296838 endingPage "1368" @default.
• W2764296838 startingPage "1368" @default.
• W2764296838 abstract "<h3>Importance</h3> Visual impairment in primary central nervous system lymphoma (PCNSL) is caused mostly by intraocular lymphomatous involvement (vitritis and retinal infiltration), whereas optic nerve infiltration (ONI) is a rare condition. <h3>Objective</h3> To describe the clinical presentation of ONI, its imaging characteristics, and outcome. <h3>Design, Setting and Participants</h3> A total of 752 patients diagnosed with PCNSL were retrospectively identified from the databases of 3 French hospitals from January 1, 1998, through December 31, 2014. Of these, 7 patients had documented ONI. Exclusion criteria were intraocular involvement, orbital lymphoma, or other systemic lymphoma. Clinical presentation, neuroimaging, biological features, treatment, and outcomes were assessed. <h3>Main Outcomes and Measures</h3> Treatment response was evaluated clinically and radiologically on follow-up magnetic resonance imaging (MRI) according to the International PCNSL Collaborative Group response criteria. <h3>Results</h3> The 7 patients included 5 women and 2 men. Median age at diagnosis was 65 years (range, 49-78 years). Two patients had initial ONI at diagnosis, and 5 had ONI at relapse. Clinical presentation was marked by rapidly progressive and severe visual impairment for all patients. The MRI findings showed optic nerve enlargement in 3 patients and contrast enhancement of the optic nerve in all patients. Additional CNS lesions were seen in 4 patients. Examination of cerebrospinal fluid samples detected lymphomatous meningitis in 2 patients. Clinical outcome was poor and marked by partial recovery for 2 patients and persistent severe low visual acuity or blindness for 5 patients. Median progression-free survival after optic nerve infiltration was 11 months (95% CI, 9-13 months), and median overall survival was 18 months (95% CI, 9-27 months). <h3>Conclusions and Relevance</h3> Optic nerve infiltration is an atypical and challenging presentation of PCNSL. Its visual and systemic prognosis is particularly poor compared with vitreoretinal lymphomas even in response to chemotherapy. Although intraocular involvement is frequent in PCNSL and clinically marked by slowly progressive visual deterioration, lymphomatous ONI is rare and characterized by rapidly progressive severe visual impairment." @default.
• W2764296838 created "2017-10-20" @default.
• W2764296838 creator A5003368354 @default.
• W2764296838 creator A5007264493 @default.
• W2764296838 creator A5011185863 @default.
• W2764296838 creator A5012409046 @default.
• W2764296838 creator A5013011705 @default.
• W2764296838 creator A5024226918 @default.
• W2764296838 creator A5025406754 @default.
• W2764296838 creator A5028792538 @default.
• W2764296838 creator A5030570042 @default.
• W2764296838 creator A5062918190 @default.
• W2764296838 creator A5072571593 @default.
• W2764296838 creator A5084107178 @default.
• W2764296838 date "2017-11-01" @default.
• W2764296838 modified "2023-10-18" @default.
• W2764296838 title "Optic Nerve Infiltration in Primary Central Nervous System Lymphoma" @default.
• W2764296838 cites W1592304769 @default.
• W2764296838 cites W1605541716 @default.
• W2764296838 cites W1966424580 @default.
• W2764296838 cites W1983979831 @default.
• W2764296838 cites W1996453907 @default.
• W2764296838 cites W2001307779 @default.
• W2764296838 cites W2007099901 @default.
• W2764296838 cites W2050667838 @default.
• W2764296838 cites W2055507330 @default.
• W2764296838 cites W2055926684 @default.
• W2764296838 cites W2058486825 @default.
• W2764296838 cites W2067963518 @default.
• W2764296838 cites W2080306023 @default.
• W2764296838 cites W2089985280 @default.
• W2764296838 cites W2114203274 @default.
• W2764296838 cites W2149603266 @default.
• W2764296838 cites W2152089976 @default.
• W2764296838 cites W2152683795 @default.
• W2764296838 cites W2166261719 @default.
• W2764296838 cites W2166505783 @default.
• W2764296838 cites W2294816409 @default.
• W2764296838 cites W2347099355 @default.
• W2764296838 cites W2551396246 @default.
• W2764296838 doi "https://doi.org/10.1001/jamaneurol.2017.2545" @default.
• W2764296838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5710580" @default.
• W2764296838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28973119" @default.
• W2764296838 hasPublicationYear "2017" @default.
• W2764296838 type Work @default.
• W2764296838 sameAs 2764296838 @default.
• W2764296838 citedByCount "16" @default.
• W2764296838 countsByYear W27642968382018 @default.
• W2764296838 countsByYear W27642968382019 @default.
• W2764296838 countsByYear W27642968382020 @default.
• W2764296838 countsByYear W27642968382021 @default.
• W2764296838 countsByYear W27642968382022 @default.
• W2764296838 countsByYear W27642968382023 @default.
• W2764296838 crossrefType "journal-article" @default.
• W2764296838 hasAuthorship W2764296838A5003368354 @default.
• W2764296838 hasAuthorship W2764296838A5007264493 @default.
• W2764296838 hasAuthorship W2764296838A5011185863 @default.
• W2764296838 hasAuthorship W2764296838A5012409046 @default.
• W2764296838 hasAuthorship W2764296838A5013011705 @default.
• W2764296838 hasAuthorship W2764296838A5024226918 @default.
• W2764296838 hasAuthorship W2764296838A5025406754 @default.
• W2764296838 hasAuthorship W2764296838A5028792538 @default.
• W2764296838 hasAuthorship W2764296838A5030570042 @default.
• W2764296838 hasAuthorship W2764296838A5062918190 @default.
• W2764296838 hasAuthorship W2764296838A5072571593 @default.
• W2764296838 hasAuthorship W2764296838A5084107178 @default.
• W2764296838 hasBestOaLocation W27642968381 @default.
• W2764296838 hasConcept C118487528 @default.
• W2764296838 hasConcept C118552586 @default.
• W2764296838 hasConcept C126838900 @default.
• W2764296838 hasConcept C141071460 @default.
• W2764296838 hasConcept C142724271 @default.
• W2764296838 hasConcept C143409427 @default.
• W2764296838 hasConcept C16568411 @default.
• W2764296838 hasConcept C2778007619 @default.
• W2764296838 hasConcept C2778257484 @default.
• W2764296838 hasConcept C2779338263 @default.
• W2764296838 hasConcept C2780837183 @default.
• W2764296838 hasConcept C2781173314 @default.
• W2764296838 hasConcept C71924100 @default.
• W2764296838 hasConceptScore W2764296838C118487528 @default.
• W2764296838 hasConceptScore W2764296838C118552586 @default.
• W2764296838 hasConceptScore W2764296838C126838900 @default.
• W2764296838 hasConceptScore W2764296838C141071460 @default.
• W2764296838 hasConceptScore W2764296838C142724271 @default.
• W2764296838 hasConceptScore W2764296838C143409427 @default.
• W2764296838 hasConceptScore W2764296838C16568411 @default.
• W2764296838 hasConceptScore W2764296838C2778007619 @default.
• W2764296838 hasConceptScore W2764296838C2778257484 @default.
• W2764296838 hasConceptScore W2764296838C2779338263 @default.
• W2764296838 hasConceptScore W2764296838C2780837183 @default.
• W2764296838 hasConceptScore W2764296838C2781173314 @default.
• W2764296838 hasConceptScore W2764296838C71924100 @default.
• W2764296838 hasIssue "11" @default.
• W2764296838 hasLocation W27642968381 @default.
• W2764296838 hasLocation W27642968382 @default.
• W2764296838 hasLocation W27642968383 @default.
• W2764296838 hasLocation W27642968384 @default.

• next