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- W2764304191 endingPage "262" @default.
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- W2764304191 abstract "Ebola virus is a highly pathogenic member of the family Filoviridae that causes a severe hemorrhagic disease in humans and NHP. The 2013-2016 West African outbreak has increased interest in the development and refinement of animal models of Ebola virus disease. These models are used to test countermeasures and vaccines, gain scientific insights into the mechanisms of disease progression and transmission, and study key correlates of immunology. Ebola virus is classified as a BSL4 pathogen and Category A agent, for which the United States government requires preparedness in case of bioterrorism. Rodents, such as Syrian golden hamsters (Mesocricetus auratus), mice (Mus musculus), and guinea pigs (Cavia porcellus), are the most common research species. However, NHP, especially macaques, are favored for Ebola virus disease research due to similarities with humans regarding the pathogenesis, clinical presentation, laboratory findings, and causes of fatality. To satisfy the regulatory requirements for approval of countermeasures against high-consequence pathogens, the FDA instituted the Animal Rule, which permits efficacy studies in animal models in place of human clinical data when such studies are not feasible or ethical. This review provides a comprehensive summary of various animal models and their use in Ebola virus disease research." @default.
- W2764304191 created "2017-10-20" @default.
- W2764304191 creator A5002200575 @default.
- W2764304191 creator A5067561610 @default.
- W2764304191 creator A5083473183 @default.
- W2764304191 creator A5084663649 @default.
- W2764304191 date "2017-06-01" @default.
- W2764304191 modified "2023-09-27" @default.
- W2764304191 title "Animal Models of Ebolavirus Infection." @default.
- W2764304191 cites W1177534810 @default.
- W2764304191 cites W1266297804 @default.
- W2764304191 cites W1510487586 @default.
- W2764304191 cites W1759518163 @default.
- W2764304191 cites W1781829305 @default.
- W2764304191 cites W1858326347 @default.
- W2764304191 cites W1896140847 @default.
- W2764304191 cites W1902122130 @default.
- W2764304191 cites W1922738695 @default.
- W2764304191 cites W1937339698 @default.
- W2764304191 cites W1974004596 @default.
- W2764304191 cites W1975525323 @default.
- W2764304191 cites W1975876487 @default.
- W2764304191 cites W1982830459 @default.
- W2764304191 cites W1985403315 @default.
- W2764304191 cites W1986492410 @default.
- W2764304191 cites W1986546565 @default.
- W2764304191 cites W1987080862 @default.
- W2764304191 cites W1990839309 @default.
- W2764304191 cites W1993913454 @default.
- W2764304191 cites W2004044377 @default.
- W2764304191 cites W2006635133 @default.
- W2764304191 cites W2011910693 @default.
- W2764304191 cites W2013018787 @default.
- W2764304191 cites W2015010736 @default.
- W2764304191 cites W2019209892 @default.
- W2764304191 cites W2022659608 @default.
- W2764304191 cites W2024123171 @default.
- W2764304191 cites W2029609222 @default.
- W2764304191 cites W2030250036 @default.
- W2764304191 cites W2031029394 @default.
- W2764304191 cites W2035920820 @default.
- W2764304191 cites W2041549933 @default.
- W2764304191 cites W2046182783 @default.
- W2764304191 cites W2049320958 @default.
- W2764304191 cites W2054182181 @default.
- W2764304191 cites W2059880041 @default.
- W2764304191 cites W2061656901 @default.
- W2764304191 cites W2063588861 @default.
- W2764304191 cites W2072075382 @default.
- W2764304191 cites W2078836794 @default.
- W2764304191 cites W2079928928 @default.
- W2764304191 cites W2081442068 @default.
- W2764304191 cites W2086534263 @default.
- W2764304191 cites W2092691854 @default.
- W2764304191 cites W2094139772 @default.
- W2764304191 cites W2094993149 @default.
- W2764304191 cites W2098900577 @default.
- W2764304191 cites W2101345948 @default.
- W2764304191 cites W2101872019 @default.
- W2764304191 cites W2103329564 @default.
- W2764304191 cites W2103802172 @default.
- W2764304191 cites W2106603184 @default.
- W2764304191 cites W2108012742 @default.
- W2764304191 cites W2108356414 @default.
- W2764304191 cites W2108945732 @default.
- W2764304191 cites W2110608820 @default.
- W2764304191 cites W2113224494 @default.
- W2764304191 cites W2114356369 @default.
- W2764304191 cites W2115065945 @default.
- W2764304191 cites W2115439758 @default.
- W2764304191 cites W2117671399 @default.
- W2764304191 cites W2117935598 @default.
- W2764304191 cites W2121706409 @default.
- W2764304191 cites W2121895001 @default.
- W2764304191 cites W2123944257 @default.
- W2764304191 cites W2125684318 @default.
- W2764304191 cites W2126447662 @default.
- W2764304191 cites W2131909499 @default.
- W2764304191 cites W2132345575 @default.
- W2764304191 cites W2133600490 @default.
- W2764304191 cites W2142580584 @default.
- W2764304191 cites W2145340095 @default.
- W2764304191 cites W2149484246 @default.
- W2764304191 cites W2162730915 @default.
- W2764304191 cites W2163858364 @default.
- W2764304191 cites W2167092519 @default.
- W2764304191 cites W2169240411 @default.
- W2764304191 cites W2172130385 @default.
- W2764304191 cites W2199092396 @default.
- W2764304191 cites W2236364162 @default.
- W2764304191 cites W2249015911 @default.
- W2764304191 cites W2286713827 @default.
- W2764304191 cites W2320122886 @default.
- W2764304191 cites W2328924450 @default.
- W2764304191 cites W2336471513 @default.
- W2764304191 cites W2344740792 @default.
- W2764304191 cites W2390167325 @default.
- W2764304191 cites W23995963 @default.