FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2764309635> ?p ?o ?g. }

• W2764309635 endingPage "3653" @default.
• W2764309635 startingPage "3644" @default.
• W2764309635 abstract "Abstract Neutrophils are of fundamental importance in the early immune response and use various mechanisms to neutralize invading pathogens. They kill endocytosed pathogens by releasing reactive oxygen species in the phagosome and release neutrophil extracellular traps (NETs) into their surroundings to immobilize and kill invading micro-organisms. Filamin A (FlnA) is an important actin cross-linking protein that is required for cellular processes involving actin rearrangements, such cell migration. It has also been shown to negatively regulate integrin activation and adhesion. However, its role in the regulation of β2 integrin–dependent adhesion, as well as in other cellular functions in neutrophils, is poorly understood. Using a transgenic mouse model in which FlnA is selectively depleted in myeloid cells, such as neutrophils, we show that FlnA negatively regulates β2 integrin adhesion to complement component iC3b and ICAM-1 in shear-free, but not shear-flow, conditions. FlnA deletion does not affect phagocytosis of Escherichia coli or Staphylococcus aureus or their intracellular killing. However, FlnA negatively regulates production of reactive oxygen species upon cell activation. Conversely, neutrophil activation through TLR4, as well as through activation by the Gram-negative bacteria E. coli, results in reduced NET production in FlnA-depleted neutrophils. Thus, FlnA is a negative regulator of β2 integrin–dependent cell adhesion and reactive oxygen species production but is required for NET production in primary murine neutrophils." @default.
• W2764309635 created "2017-10-20" @default.
• W2764309635 creator A5007586195 @default.
• W2764309635 creator A5010096923 @default.
• W2764309635 creator A5026985144 @default.
• W2764309635 creator A5082935308 @default.
• W2764309635 creator A5085091768 @default.
• W2764309635 date "2017-11-15" @default.
• W2764309635 modified "2023-09-26" @default.
• W2764309635 title "Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release" @default.
• W2764309635 cites W1175152041 @default.
• W2764309635 cites W1595293335 @default.
• W2764309635 cites W1775487584 @default.
• W2764309635 cites W1972516366 @default.
• W2764309635 cites W1973705216 @default.
• W2764309635 cites W1976796981 @default.
• W2764309635 cites W1985432448 @default.
• W2764309635 cites W1994331544 @default.
• W2764309635 cites W1998222520 @default.
• W2764309635 cites W1998701837 @default.
• W2764309635 cites W2011145349 @default.
• W2764309635 cites W2011473183 @default.
• W2764309635 cites W2013841398 @default.
• W2764309635 cites W2017107244 @default.
• W2764309635 cites W2025437846 @default.
• W2764309635 cites W2026181426 @default.
• W2764309635 cites W2029022410 @default.
• W2764309635 cites W2030193400 @default.
• W2764309635 cites W2032227357 @default.
• W2764309635 cites W2040287935 @default.
• W2764309635 cites W2040880223 @default.
• W2764309635 cites W2041025244 @default.
• W2764309635 cites W2043222263 @default.
• W2764309635 cites W2049324563 @default.
• W2764309635 cites W2057149060 @default.
• W2764309635 cites W206318450 @default.
• W2764309635 cites W2071617241 @default.
• W2764309635 cites W2084569322 @default.
• W2764309635 cites W2085939052 @default.
• W2764309635 cites W2092604129 @default.
• W2764309635 cites W2101346022 @default.
• W2764309635 cites W2102783132 @default.
• W2764309635 cites W2105074038 @default.
• W2764309635 cites W2124053776 @default.
• W2764309635 cites W2125815072 @default.
• W2764309635 cites W2128445597 @default.
• W2764309635 cites W2130704297 @default.
• W2764309635 cites W2146476684 @default.
• W2764309635 cites W2148126606 @default.
• W2764309635 cites W2151403120 @default.
• W2764309635 cites W2154415816 @default.
• W2764309635 cites W2169535061 @default.
• W2764309635 cites W2270368321 @default.
• W2764309635 cites W2337024033 @default.
• W2764309635 cites W39814539 @default.
• W2764309635 doi "https://doi.org/10.4049/jimmunol.1700087" @default.
• W2764309635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28986439" @default.
• W2764309635 hasPublicationYear "2017" @default.
• W2764309635 type Work @default.
• W2764309635 sameAs 2764309635 @default.
• W2764309635 citedByCount "19" @default.
• W2764309635 countsByYear W27643096352018 @default.
• W2764309635 countsByYear W27643096352019 @default.
• W2764309635 countsByYear W27643096352020 @default.
• W2764309635 countsByYear W27643096352021 @default.
• W2764309635 countsByYear W27643096352022 @default.
• W2764309635 countsByYear W27643096352023 @default.
• W2764309635 crossrefType "journal-article" @default.
• W2764309635 hasAuthorship W2764309635A5007586195 @default.
• W2764309635 hasAuthorship W2764309635A5010096923 @default.
• W2764309635 hasAuthorship W2764309635A5026985144 @default.
• W2764309635 hasAuthorship W2764309635A5082935308 @default.
• W2764309635 hasAuthorship W2764309635A5085091768 @default.
• W2764309635 hasBestOaLocation W27643096351 @default.
• W2764309635 hasConcept C134897094 @default.
• W2764309635 hasConcept C142669718 @default.
• W2764309635 hasConcept C1491633281 @default.
• W2764309635 hasConcept C171779818 @default.
• W2764309635 hasConcept C185592680 @default.
• W2764309635 hasConcept C195687474 @default.
• W2764309635 hasConcept C203014093 @default.
• W2764309635 hasConcept C20563397 @default.
• W2764309635 hasConcept C2776914184 @default.
• W2764309635 hasConcept C2779684405 @default.
• W2764309635 hasConcept C48349386 @default.
• W2764309635 hasConcept C553184892 @default.
• W2764309635 hasConcept C55493867 @default.
• W2764309635 hasConcept C85789140 @default.
• W2764309635 hasConcept C86803240 @default.
• W2764309635 hasConcept C95444343 @default.
• W2764309635 hasConceptScore W2764309635C134897094 @default.
• W2764309635 hasConceptScore W2764309635C142669718 @default.
• W2764309635 hasConceptScore W2764309635C1491633281 @default.
• W2764309635 hasConceptScore W2764309635C171779818 @default.
• W2764309635 hasConceptScore W2764309635C185592680 @default.
• W2764309635 hasConceptScore W2764309635C195687474 @default.
• W2764309635 hasConceptScore W2764309635C203014093 @default.
• W2764309635 hasConceptScore W2764309635C20563397 @default.

• next