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• W2764335093 abstract "Over the past few years, direct oral anticoagulants (DOACs) have been gradually replacing warfarin. Inappropriate prescribing of DOACs in real-life practice settings can affect their perceived safety and efficacy, especially with the lack of a surrogate marker for guidance.To describe the appropriateness of DOACs prescribing, compare dabigatran to rivaroxaban in terms of inappropriate prescribing, and determine other factors associated with inappropriate DOACs use.In this cross-sectional retrospective study, 5-year DOAC prescriptions data were extracted. Appropriateness was evaluated based on approved dosing and indications in Canada and the United States. Descriptive and inferential statistics were performed using SPSS.From 2011 to 2015, there were 1049 DOACs prescriptions, among which 572 (54.5%) were for dabigatran and 477(45.5%) were for rivaroxaban. The DOACs were prescribed for inappropriate indication in 35 (3.3%) patients, while inappropriate dosing was found in 352 (33.6%) prescriptions. There were significantly more inappropriate dabigatran prescriptions compared to rivaroxaban both in terms of indication (4.7% vs 1.7%, P = .004) and dosing (50.9% vs 12.8%, P < .001). Logistic regression analysis confirmed that dabigatran prescribing was the only factor associated with inappropriate indications (odds ratio [OR] = 2.9, 95% confidence interval [CI]: 1.3-6.5). Factors associated with inappropriate dosing included dabigatran prescriptions (OR = 7.6, 95% CI: 5.5-10.5) and poor renal function (OR = 14.6, 95% CI: 3.6-58.4).Direct oral anticoagulants have been gradually replacing warfarin in Qatar; however, they are not always prescribed appropriately especially in patients on dabigatran and those with renal impairment. Educating health-care practitioners is necessary. Future studies comparing the clinical safety and effectiveness of the DOACs especially when used at an inappropriate dose are also warranted." @default.
• W2764335093 created "2017-10-20" @default.
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• W2764335093 date "2017-10-04" @default.
• W2764335093 modified "2023-09-26" @default.
• W2764335093 title "Appropriateness of Dabigatran and Rivaroxaban Prescribing in Qatar: A 5-Year Experience" @default.
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• W2764335093 doi "https://doi.org/10.1177/1074248417731536" @default.
• W2764335093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28978236" @default.
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