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- W2764759516 abstract "There is evidence to suggest that organic cerebral changes occur in elderly depressed patients. Quantitative studies of elderly depressed patients have demonstrated that they have reduced ‘radio-attenuation’ on computerised tomography (CT) scans and as a group resembled more closely a group of demented patients than normal controls (Jacoby et al , 1983). Many biochemical changes associated with ageing are similar to the pathophysiological abnormalities in depression and in dementia (Alexopoulos et al , 1988). These changes, coupled with the high frequency of depressive syndromes in demented patients, suggest a complex relationship between depression and dementia in old age. Mahendra (1985) has suggested that a variety of brain abnormalities can produce a spectrum of clinical manifestations, ranging from depression with minimal cognitive dysfunction at one end to dementia with minimal depression at the other." @default.
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- W2764759516 date "1990-12-01" @default.
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- W2764759516 title "A Study of Depression in Old Age Using Single-Photon Emission Computerised Tomography" @default.
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- W2764759516 doi "https://doi.org/10.1192/s0007125000291873" @default.
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