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- W2765033684 endingPage "352" @default.
- W2765033684 startingPage "281" @default.
- W2765033684 abstract "An inherited disease is the one in which the condition is determined, wholly or in part, by the genetic constitution with which the organism started its development. The genetic constitution of an organism is made up of discrete, stable units, with the genes that are carried in the chromosomes in linear order. Genetic susceptibility, estrogenic stimulation, and the virus-like milk agent are primary causative influences. The actions and interactions of all and, in certain circumstances, a combination of two increase the probability that mammary cancer will occur. The basic change from normal to leukemic, which is intrinsic to the cell, may be the result of an alteration of the reproductive material of the cell. The specific genes that have been identified as influencing susceptibility to leukemia could conceivably do so by producing gene mutations in the body cell. The somatic mutation theory maintains that cancer is a consequence of the mutation of a gene in a body cell. Many genes appear to be involved in determining susceptibility to each of the neoplasms investigated. These genes are cumulative in effect. The argument that transplantable tumors contribute little to the understanding of the etiology of cancer is quite sterile. A consistent relationship was found between the chromosome constitution of the tumor cells and transplantability." @default.
- W2765033684 created "2017-10-27" @default.
- W2765033684 creator A5034888318 @default.
- W2765033684 date "1954-01-01" @default.
- W2765033684 modified "2023-10-18" @default.
- W2765033684 title "Genetic Studies in Experimental Cancer" @default.
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