Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765085373> ?p ?o ?g. }
- W2765085373 endingPage "87" @default.
- W2765085373 startingPage "75" @default.
- W2765085373 abstract "Introduction: The overexpression of matrix metalloproteinase (MMP) plays an important role in the context of tumor invasion and metastasis, and MMP-2 has been characterized as the most validated target for cancer. Therefore, it is necessary to design matrix metalloproteinase inhibitors (MMPIs) that would be active and selective against MMP-2 but non-selective toward other MMPs.Areas covered: This article clearly describes the structural character of MMP-2 followed by a review of the recent development of selective MMP-2 inhibitors based on their basic structures.Expert opinion: Over the past 30 years, MMPs have been considered to be attractive cancer targets, and several different types of synthetic inhibitors have been identified as anticancer agents, but only a small number of small MMPIs have been examined in clinical trials, and none of these molecules has been established as anticancer drugs due to their adverse effects. One major possibility is that the MMPIs used in clinical trials were broad-spectrum drugs that also inhibited the anti-tumor effects and influenced the mediation of the normal physiological processes of MMPs. MMP-2 has recently been characterized as the most validated target for cancer. Therefore, the design and synthesis of selective MMP-2 inhibitors would be helpful for the treatment of cancer." @default.
- W2765085373 created "2017-11-10" @default.
- W2765085373 creator A5006443043 @default.
- W2765085373 creator A5048389767 @default.
- W2765085373 creator A5049739479 @default.
- W2765085373 creator A5055999528 @default.
- W2765085373 creator A5059560149 @default.
- W2765085373 creator A5070060890 @default.
- W2765085373 creator A5086207660 @default.
- W2765085373 date "2017-10-31" @default.
- W2765085373 modified "2023-10-18" @default.
- W2765085373 title "Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer" @default.
- W2765085373 cites W1561847131 @default.
- W2765085373 cites W1576210721 @default.
- W2765085373 cites W1641625687 @default.
- W2765085373 cites W1818505718 @default.
- W2765085373 cites W1902505213 @default.
- W2765085373 cites W1927710162 @default.
- W2765085373 cites W1928161708 @default.
- W2765085373 cites W1935517563 @default.
- W2765085373 cites W1963698879 @default.
- W2765085373 cites W1965498876 @default.
- W2765085373 cites W1965999026 @default.
- W2765085373 cites W1967563466 @default.
- W2765085373 cites W1972699105 @default.
- W2765085373 cites W1975031208 @default.
- W2765085373 cites W1977023514 @default.
- W2765085373 cites W1977959160 @default.
- W2765085373 cites W1978206693 @default.
- W2765085373 cites W1978591675 @default.
- W2765085373 cites W1979862046 @default.
- W2765085373 cites W1980069165 @default.
- W2765085373 cites W1985590246 @default.
- W2765085373 cites W1992588954 @default.
- W2765085373 cites W1993322814 @default.
- W2765085373 cites W1993997117 @default.
- W2765085373 cites W1995249913 @default.
- W2765085373 cites W1997541998 @default.
- W2765085373 cites W1999192672 @default.
- W2765085373 cites W2000241906 @default.
- W2765085373 cites W2001921851 @default.
- W2765085373 cites W2005151288 @default.
- W2765085373 cites W2005334224 @default.
- W2765085373 cites W2005692904 @default.
- W2765085373 cites W2007361132 @default.
- W2765085373 cites W2008730025 @default.
- W2765085373 cites W2011134969 @default.
- W2765085373 cites W2011503999 @default.
- W2765085373 cites W2011966544 @default.
- W2765085373 cites W2014260136 @default.
- W2765085373 cites W2016411107 @default.
- W2765085373 cites W2016484384 @default.
- W2765085373 cites W2018881031 @default.
- W2765085373 cites W2019141246 @default.
- W2765085373 cites W2021657783 @default.
- W2765085373 cites W2022297961 @default.
- W2765085373 cites W2023916307 @default.
- W2765085373 cites W2030805052 @default.
- W2765085373 cites W2033341544 @default.
- W2765085373 cites W2034806037 @default.
- W2765085373 cites W2035410475 @default.
- W2765085373 cites W2036662231 @default.
- W2765085373 cites W2040011992 @default.
- W2765085373 cites W2041177728 @default.
- W2765085373 cites W2042792814 @default.
- W2765085373 cites W2043250294 @default.
- W2765085373 cites W2043447311 @default.
- W2765085373 cites W2044835152 @default.
- W2765085373 cites W2050652763 @default.
- W2765085373 cites W2061868832 @default.
- W2765085373 cites W2062809004 @default.
- W2765085373 cites W2063482106 @default.
- W2765085373 cites W2064969450 @default.
- W2765085373 cites W2071359561 @default.
- W2765085373 cites W2080997685 @default.
- W2765085373 cites W2081935558 @default.
- W2765085373 cites W2087973465 @default.
- W2765085373 cites W2094511972 @default.
- W2765085373 cites W2121357141 @default.
- W2765085373 cites W2124809270 @default.
- W2765085373 cites W2125753121 @default.
- W2765085373 cites W2129132817 @default.
- W2765085373 cites W2129416829 @default.
- W2765085373 cites W2130479394 @default.
- W2765085373 cites W2133499137 @default.
- W2765085373 cites W2138983924 @default.
- W2765085373 cites W2141209718 @default.
- W2765085373 cites W2141779177 @default.
- W2765085373 cites W2148401297 @default.
- W2765085373 cites W2149684226 @default.
- W2765085373 cites W2152794417 @default.
- W2765085373 cites W2154806033 @default.
- W2765085373 cites W2155879201 @default.
- W2765085373 cites W2158244671 @default.
- W2765085373 cites W2159279477 @default.
- W2765085373 cites W2162856085 @default.
- W2765085373 cites W2164308010 @default.
- W2765085373 cites W2165151298 @default.