FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765122904> ?p ?o ?g. }

• W2765122904 endingPage "34" @default.
• W2765122904 startingPage "24" @default.
• W2765122904 abstract "Total psoas area (TPA), a marker of sarcopenia, has been used as an independent predictor of clinical outcomes in gastrointestinal (GI) cancers as a proxy for frailty and nutritional status. Our study aimed to evaluate whether TPA, in contrast to traditional measurements of nutrition like body mass index (BMI) and body surface area (BSA), was predictive of outcomes in borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) patients receiving stereotactic body radiation therapy (SBRT).Retrospective analysis of an institutional review board approved database of 222 BRPC and LAPC treated with SBRT from 2009-2016 yielded 183 patients that met our selection criteria of pre-SBRT computed tomography (CT) imaging with an identifiable L4 vertebra. Once the L4 vertebral level was identified, the bilateral psoas muscles were manually contoured. This area was normalized by patient height, with units described in mm2/m2. Receiver operating characteristic (ROC) curves were generated for TPA, BMI, and BSA to elicit clinically relevant cutoffs. Regression and Kaplan-Meier analyses were used to correlate toxicity with survival functions.Low TPA (OR =1.903, P=0.036) was predictive of acute toxicities, and only TPA was predictive of Grade 3 or higher acute toxicities (OR =10.24, P=0.007). Both findings were independent of tumor resectability. Pain (P=0.003), fatigue (P=0.040), and nausea (P=0.039) were significantly associated with low TPA. No association was identified between any measurement of nutritional status and the development of late toxicities, overall survival, local progression or local recurrence. However, BRPC patients survived longer (median =21.98 months) than their LAPC (median =16.2 months) counterparts (P=0.002), independent of nutritional status.TPA measurement is readily available and more specific than BMI or BSA as a predictor of acute radiotoxic complications following SBRT in BRPC/LAPC patients. A TPA of <500 mm2/m2 is a clinically relevant cutoff that can direct physicians to address expected complications of pain, fatigue, and nausea. However, tumor resectability remains as the only predictor of overall survival in this cohort." @default.
• W2765122904 created "2017-11-10" @default.
• W2765122904 creator A5006838528 @default.
• W2765122904 creator A5011928702 @default.
• W2765122904 creator A5023129507 @default.
• W2765122904 creator A5032525529 @default.
• W2765122904 creator A5035589941 @default.
• W2765122904 creator A5062142011 @default.
• W2765122904 creator A5071445561 @default.
• W2765122904 creator A5091641523 @default.
• W2765122904 date "2018-02-01" @default.
• W2765122904 modified "2023-10-14" @default.
• W2765122904 title "Impact of sarcopenia in borderline resectable and locally advanced pancreatic cancer patients receiving stereotactic body radiation therapy" @default.
• W2765122904 cites W1481844387 @default.
• W2765122904 cites W1563283949 @default.
• W2765122904 cites W1609440971 @default.
• W2765122904 cites W1842042263 @default.
• W2765122904 cites W1896432851 @default.
• W2765122904 cites W1955067091 @default.
• W2765122904 cites W1965136089 @default.
• W2765122904 cites W1969399021 @default.
• W2765122904 cites W1971256594 @default.
• W2765122904 cites W1971940885 @default.
• W2765122904 cites W1996468870 @default.
• W2765122904 cites W1997561860 @default.
• W2765122904 cites W2003020102 @default.
• W2765122904 cites W2003211608 @default.
• W2765122904 cites W2013529703 @default.
• W2765122904 cites W2016341941 @default.
• W2765122904 cites W2019724104 @default.
• W2765122904 cites W2025088333 @default.
• W2765122904 cites W2027362748 @default.
• W2765122904 cites W2036610278 @default.
• W2765122904 cites W2041487861 @default.
• W2765122904 cites W2043737378 @default.
• W2765122904 cites W2048787455 @default.
• W2765122904 cites W2059998726 @default.
• W2765122904 cites W2063299372 @default.
• W2765122904 cites W2068101666 @default.
• W2765122904 cites W2069554919 @default.
• W2765122904 cites W2087502782 @default.
• W2765122904 cites W2088329707 @default.
• W2765122904 cites W2091193950 @default.
• W2765122904 cites W2097022747 @default.
• W2765122904 cites W2098571411 @default.
• W2765122904 cites W2101345979 @default.
• W2765122904 cites W2101398993 @default.
• W2765122904 cites W2104930742 @default.
• W2765122904 cites W2107089530 @default.
• W2765122904 cites W2111525190 @default.
• W2765122904 cites W2113464761 @default.
• W2765122904 cites W2119448420 @default.
• W2765122904 cites W2123664981 @default.
• W2765122904 cites W2131558794 @default.
• W2765122904 cites W2133085150 @default.
• W2765122904 cites W2145902876 @default.
• W2765122904 cites W2145907568 @default.
• W2765122904 cites W2162821812 @default.
• W2765122904 cites W2171267283 @default.
• W2765122904 cites W2172740061 @default.
• W2765122904 cites W2192219942 @default.
• W2765122904 cites W2219037326 @default.
• W2765122904 cites W2221436343 @default.
• W2765122904 cites W2264892838 @default.
• W2765122904 cites W2280343580 @default.
• W2765122904 cites W2285332151 @default.
• W2765122904 cites W2293035635 @default.
• W2765122904 cites W2294867706 @default.
• W2765122904 cites W2342110457 @default.
• W2765122904 cites W2342772669 @default.
• W2765122904 cites W2403094648 @default.
• W2765122904 cites W2413971556 @default.
• W2765122904 cites W2469050297 @default.
• W2765122904 cites W2477223080 @default.
• W2765122904 cites W2491586895 @default.
• W2765122904 cites W2507163020 @default.
• W2765122904 cites W2514207831 @default.
• W2765122904 cites W2528671253 @default.
• W2765122904 cites W2537721145 @default.
• W2765122904 cites W2538437806 @default.
• W2765122904 cites W2539910027 @default.
• W2765122904 cites W2545974164 @default.
• W2765122904 cites W2554987853 @default.
• W2765122904 cites W2559963991 @default.
• W2765122904 cites W2790224787 @default.
• W2765122904 cites W301751795 @default.
• W2765122904 doi "https://doi.org/10.21037/jgo.2017.09.13" @default.
• W2765122904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5848029" @default.
• W2765122904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29564168" @default.
• W2765122904 hasPublicationYear "2018" @default.
• W2765122904 type Work @default.
• W2765122904 sameAs 2765122904 @default.
• W2765122904 citedByCount "14" @default.
• W2765122904 countsByYear W27651229042018 @default.
• W2765122904 countsByYear W27651229042019 @default.
• W2765122904 countsByYear W27651229042020 @default.
• W2765122904 countsByYear W27651229042021 @default.
• W2765122904 countsByYear W27651229042022 @default.

• next