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• W2765124834 startingPage "38908" @default.
• W2765124834 abstract "Biopolymer-based multilayers become more and more attractive due to the vast span of biological application they can be used for, e.g., implant coatings, cell culture supports, scaffolds. Multilayers have demonstrated superior capability to store enormous amounts of small charged molecules, such as drugs, and release them in a controlled manner; however, the binding mechanism for drug loading into the multilayers is still poorly understood. Here we focus on this mechanism using model hyaluronan/polylysine (HA/PLL) multilayers and a model charged dye, carboxyfluorescein (CF). We found that CF reaches a concentration of 13 mM in the multilayers that by far exceeds its solubility in water. The high loading is not related to the aggregation of CF in the multilayers. In the multilayers, CF molecules bind to free amino groups of PLL; however, intermolecular CF–CF interactions also play a role and (i) endow the binding with a cooperative nature and (ii) result in polyadsorption of CF molecules, as proven by fitting of the adsorption isotherm using the BET model. Analysis of CF mobility in the multilayers by fluorescence recovery after photobleaching has revealed that CF diffusion in the multilayers is likely a result of both jumping of CF molecules from one amino group to another and movement, together with a PLL chain being bound to it. We believe that this study may help in the design of tailor-made multilayers that act as advanced drug delivery platforms for a variety of bioapplications where high loading and controlled release are strongly desired." @default.
• W2765124834 created "2017-11-10" @default.
• W2765124834 creator A5004724813 @default.
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• W2765124834 date "2017-10-24" @default.
• W2765124834 modified "2023-10-17" @default.
• W2765124834 title "Binding Mechanism of the Model Charged Dye Carboxyfluorescein to Hyaluronan/Polylysine Multilayers" @default.
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• W2765124834 doi "https://doi.org/10.1021/acsami.7b12449" @default.
• W2765124834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5682609" @default.
• W2765124834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29035502" @default.
• W2765124834 hasPublicationYear "2017" @default.
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