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- W2765135072 abstract "Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes." @default.
- W2765135072 created "2017-11-10" @default.
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- W2765135072 creator A5038554858 @default.
- W2765135072 date "2017-11-06" @default.
- W2765135072 modified "2023-10-05" @default.
- W2765135072 title "Weak correlations between hemodynamic signals and ongoing neural activity during the resting state" @default.
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- W2765135072 doi "https://doi.org/10.1038/s41593-017-0007-y" @default.
- W2765135072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5816345" @default.
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- W2765135072 hasPublicationYear "2017" @default.
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