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- W2765151695 abstract "To quantify and characterize the toxic protein aggregates associated with neurodegenerative diseases, an ultra-sensitive assay based on measuring the amount of aggregate induced Ca2+ influx into individual immobilized lipid vesicles has been developed. Quantitative high-throughput fluorescence imaging of Ca2+ influx into individual surface-tethered lipid vesicles imaged using Total Internal Reflection based Fluorescence technique. We have developed a single vesicle assay to measure the oligomer induced Ca2+ influx inside the individual liposomes. The extent of increased Ca2+ concentration in individual liposomes is essentially the measure of cytotoxicity induced by oligomers. We have measured the toxicity of synthetic oligomers as a function of oligomer concentration and liposome membrane composition, and are able to maximise the sensitivity of this assay. Using this ultra-sensitive strategy, we are able to quantify the cerebrospinal fluid (CSF) induced calcium influx for both healthy controls and patients with Alzheimer's disease. We also monitor the effect of various antibodies developed for the treatment of AD on the toxicity of synthetic oligomers and those in CSF to find one which are effective and hence identify the accessible epitopes on the oligomers." @default.
- W2765151695 created "2017-11-10" @default.
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- W2765151695 date "2017-07-01" @default.
- W2765151695 modified "2023-09-28" @default.
- W2765151695 title "[P3-074]: AN ULTRA-SENSITIVE ASSAY TO MEASURE AGGREGATE INDUCED CA2+ INFLUX IN HUMAN CEREBROSPINAL FLUID" @default.
- W2765151695 doi "https://doi.org/10.1016/j.jalz.2017.06.1284" @default.
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