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- W2765160147 abstract "Abstract MicroRNAs (miRNAs) are 19–22 nt-long RNA molecules that mediate posttranscriptional gene silencing. Since their discovery in Caenorhabditis elegans , miRNAs gained attention after a plethora of reports suggested their contribution to cell fate commitment, cellular plasticity, and cancer. Tumorigenesis often involves tumor-cell autonomous progressive, even stochastic, accumulation of a series of genetic and epigenetic changes, somatic mutations, and genomic instability that eventually transform into an overt malignant phenotype. Hallmarks of cancer further highlight importance of tissue-resident cancer stem cells, tumor-initiating cells, and cross talk between tumor cells within the mesenchymal microenvironment, as an important prognostic index in cancer development. Fluctuation in miRNA levels causes derepression of gene expression and could lead to tumor cell dedifferentiation. In the following sections, we illustrate miRNA involvement across the crucial hallmarks of tumorigenesis. Given the current understanding of miRNA regulation in cancer, synthetic regulation with miRNA mimics and therapeutic intervention would play a key role in cancer prevention." @default.
- W2765160147 created "2017-11-10" @default.
- W2765160147 creator A5021535721 @default.
- W2765160147 creator A5027506181 @default.
- W2765160147 creator A5051496576 @default.
- W2765160147 creator A5080959843 @default.
- W2765160147 date "2018-01-01" @default.
- W2765160147 modified "2023-09-26" @default.
- W2765160147 title "miRNA and Cancer" @default.
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