Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765172858> ?p ?o ?g. }
- W2765172858 endingPage "368" @default.
- W2765172858 startingPage "358" @default.
- W2765172858 abstract "Licorice (Glycyrrhizae Radix or Liquiritiae Radix) is traditionally used to treat various diseases including inflammation and gastric ulcers. Licorice is rich in flavonoid compounds and possesses anti-inflammatory activities. To investigate the protective effects of licorice flavonoids (LFs) in both acetic acid-induced and dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) mouse model and its underlying mechanism. Acute UC was induced by intra-rectal acetic acid (4% v/v) after pretreatment with LFs (100, 200, and 400 mg/kg, p.o.), 0.9% saline (20 mL/kg, p.o.) or Sulfasalazine (SASP) (600 mg/kg, p.o.) for 10 d. Quantitative analysis of chemical components of LFs was also conducted by HPLC. Our results showed that pre-treatment with LFs significantly reduced the wet weight/length ratio of colon, percentage of affected area, macroscopic and histological damage scores in acid-induced UC mice. LFs also significantly decreased the oxidative stress and pro-inflammatory cytokines, upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and downregulated nuclear transcription factor kappa B (NF-κB) pathway. At last, LFs also showed obvious antiulcer effect on the DSS-induced UC model. The major components of LFs were licochalcone A, glabrone, licoflavone, and licoflavone B. This study demonstrates that the protective effect of LFs may at least in part be due to its anti-oxidant activity through Nrf2 pathway and anti-inflammatory activity through NF-κB pathway." @default.
- W2765172858 created "2017-11-10" @default.
- W2765172858 creator A5011211358 @default.
- W2765172858 creator A5029279065 @default.
- W2765172858 creator A5045703368 @default.
- W2765172858 creator A5051352297 @default.
- W2765172858 creator A5064557438 @default.
- W2765172858 creator A5075922369 @default.
- W2765172858 date "2017-10-01" @default.
- W2765172858 modified "2023-10-07" @default.
- W2765172858 title "Anti-inflammatory and Anti-oxidant Effects of Licorice Flavonoids on Ulcerative Colitis in Mouse Model" @default.
- W2765172858 cites W1775749144 @default.
- W2765172858 cites W1971086540 @default.
- W2765172858 cites W1979992629 @default.
- W2765172858 cites W1980172418 @default.
- W2765172858 cites W1980768491 @default.
- W2765172858 cites W1983786281 @default.
- W2765172858 cites W1994884787 @default.
- W2765172858 cites W1998737485 @default.
- W2765172858 cites W2006453091 @default.
- W2765172858 cites W2008854574 @default.
- W2765172858 cites W2010485702 @default.
- W2765172858 cites W2011168613 @default.
- W2765172858 cites W2011798977 @default.
- W2765172858 cites W2013686136 @default.
- W2765172858 cites W2015747169 @default.
- W2765172858 cites W2017091837 @default.
- W2765172858 cites W2019326608 @default.
- W2765172858 cites W2024346860 @default.
- W2765172858 cites W2024450363 @default.
- W2765172858 cites W2025174582 @default.
- W2765172858 cites W2026679422 @default.
- W2765172858 cites W2032468601 @default.
- W2765172858 cites W2034014920 @default.
- W2765172858 cites W2037974198 @default.
- W2765172858 cites W2040724811 @default.
- W2765172858 cites W2056131072 @default.
- W2765172858 cites W2059765353 @default.
- W2765172858 cites W2064711537 @default.
- W2765172858 cites W2078681423 @default.
- W2765172858 cites W2082404102 @default.
- W2765172858 cites W2082439167 @default.
- W2765172858 cites W2089585918 @default.
- W2765172858 cites W2090210288 @default.
- W2765172858 cites W2092801963 @default.
- W2765172858 cites W2094544968 @default.
- W2765172858 cites W2113551867 @default.
- W2765172858 cites W2128998549 @default.
- W2765172858 cites W2139185290 @default.
- W2765172858 cites W2141679700 @default.
- W2765172858 cites W2142204504 @default.
- W2765172858 cites W2156953890 @default.
- W2765172858 cites W2167115441 @default.
- W2765172858 cites W2327236643 @default.
- W2765172858 cites W2327332269 @default.
- W2765172858 cites W4293247451 @default.
- W2765172858 cites W80702453 @default.
- W2765172858 cites W1987619433 @default.
- W2765172858 doi "https://doi.org/10.1016/s1674-6384(17)60116-3" @default.
- W2765172858 hasPublicationYear "2017" @default.
- W2765172858 type Work @default.
- W2765172858 sameAs 2765172858 @default.
- W2765172858 citedByCount "23" @default.
- W2765172858 countsByYear W27651728582018 @default.
- W2765172858 countsByYear W27651728582019 @default.
- W2765172858 countsByYear W27651728582021 @default.
- W2765172858 countsByYear W27651728582022 @default.
- W2765172858 countsByYear W27651728582023 @default.
- W2765172858 crossrefType "journal-article" @default.
- W2765172858 hasAuthorship W2765172858A5011211358 @default.
- W2765172858 hasAuthorship W2765172858A5029279065 @default.
- W2765172858 hasAuthorship W2765172858A5045703368 @default.
- W2765172858 hasAuthorship W2765172858A5051352297 @default.
- W2765172858 hasAuthorship W2765172858A5064557438 @default.
- W2765172858 hasAuthorship W2765172858A5075922369 @default.
- W2765172858 hasConcept C126322002 @default.
- W2765172858 hasConcept C142724271 @default.
- W2765172858 hasConcept C164027704 @default.
- W2765172858 hasConcept C181199279 @default.
- W2765172858 hasConcept C185592680 @default.
- W2765172858 hasConcept C203014093 @default.
- W2765172858 hasConcept C204787440 @default.
- W2765172858 hasConcept C2775838275 @default.
- W2765172858 hasConcept C2775862500 @default.
- W2765172858 hasConcept C2776151105 @default.
- W2765172858 hasConcept C2776673659 @default.
- W2765172858 hasConcept C2776914184 @default.
- W2765172858 hasConcept C2777397205 @default.
- W2765172858 hasConcept C2778993495 @default.
- W2765172858 hasConcept C2779134260 @default.
- W2765172858 hasConcept C2779383735 @default.
- W2765172858 hasConcept C2779703632 @default.
- W2765172858 hasConcept C2780479503 @default.
- W2765172858 hasConcept C538909803 @default.
- W2765172858 hasConcept C55493867 @default.
- W2765172858 hasConcept C556039675 @default.
- W2765172858 hasConcept C71924100 @default.
- W2765172858 hasConcept C98274493 @default.