Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765206989> ?p ?o ?g. }
- W2765206989 endingPage "897" @default.
- W2765206989 startingPage "886" @default.
- W2765206989 abstract "Human induced pluripotent stem cell (iPSC) lines are a promising model for the early phase of human embryonic development. Here, their contribution to the still incompletely understood pathogenesis of congenital virus infections was evaluated. The infection of iPSC lines with miscarriage-associated coxsackievirus B3 (CVB3) and measles virus (MV) was compared to the efficient teratogen rubella virus (RV). While CVB3 and MV were found to be cytopathogenic on iPSC lines, RV replicated without impairment of iPSC colony morphology and integrity. This so far outstanding course of infection enabled maintenance of RV-infected iPSC cultures over several passages and their subsequent differentiation to ectoderm, endoderm, and mesoderm. A modification of the metabolic profile of infected iPSC lines was the only common aspect for all three viruses. This study points toward two important aspects. First, iPSC lines represent a suitable cell culture model for early embryonic virus infection. Second, metabolic activity represents an important means for evaluation of pathogen-associated alterations in iPSC lines." @default.
- W2765206989 created "2017-11-10" @default.
- W2765206989 creator A5005526290 @default.
- W2765206989 creator A5041527004 @default.
- W2765206989 creator A5043595820 @default.
- W2765206989 creator A5057853538 @default.
- W2765206989 creator A5066621039 @default.
- W2765206989 creator A5068871940 @default.
- W2765206989 creator A5074506044 @default.
- W2765206989 creator A5078738161 @default.
- W2765206989 creator A5088343134 @default.
- W2765206989 date "2017-10-26" @default.
- W2765206989 modified "2023-10-18" @default.
- W2765206989 title "Infection of iPSC Lines with Miscarriage-Associated Coxsackievirus and Measles Virus and Teratogenic Rubella Virus as a Model for Viral Impairment of Early Human Embryogenesis" @default.
- W2765206989 cites W1490614345 @default.
- W2765206989 cites W1767876710 @default.
- W2765206989 cites W1942393720 @default.
- W2765206989 cites W1957020362 @default.
- W2765206989 cites W1963974588 @default.
- W2765206989 cites W1969196782 @default.
- W2765206989 cites W1971063609 @default.
- W2765206989 cites W1978020235 @default.
- W2765206989 cites W1988314796 @default.
- W2765206989 cites W1989498535 @default.
- W2765206989 cites W1990507071 @default.
- W2765206989 cites W2003704751 @default.
- W2765206989 cites W2008485310 @default.
- W2765206989 cites W2018369464 @default.
- W2765206989 cites W2023197475 @default.
- W2765206989 cites W2025738240 @default.
- W2765206989 cites W2039382895 @default.
- W2765206989 cites W2050605932 @default.
- W2765206989 cites W2058031612 @default.
- W2765206989 cites W2071719080 @default.
- W2765206989 cites W2086943348 @default.
- W2765206989 cites W2093166805 @default.
- W2765206989 cites W2094006394 @default.
- W2765206989 cites W2099685714 @default.
- W2765206989 cites W2104517224 @default.
- W2765206989 cites W2120192681 @default.
- W2765206989 cites W2136703579 @default.
- W2765206989 cites W2138977668 @default.
- W2765206989 cites W2142734155 @default.
- W2765206989 cites W2144202454 @default.
- W2765206989 cites W2151035052 @default.
- W2765206989 cites W2157686375 @default.
- W2765206989 cites W2163113796 @default.
- W2765206989 cites W2164706126 @default.
- W2765206989 cites W2166552936 @default.
- W2765206989 cites W2176129387 @default.
- W2765206989 cites W2183820563 @default.
- W2765206989 cites W2196729039 @default.
- W2765206989 cites W2210094278 @default.
- W2765206989 cites W2259641960 @default.
- W2765206989 cites W2292422784 @default.
- W2765206989 cites W2313711223 @default.
- W2765206989 cites W2345545607 @default.
- W2765206989 cites W2396821361 @default.
- W2765206989 cites W2413297441 @default.
- W2765206989 cites W2472845347 @default.
- W2765206989 cites W2509238591 @default.
- W2765206989 cites W2587043905 @default.
- W2765206989 doi "https://doi.org/10.1021/acsinfecdis.7b00103" @default.
- W2765206989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29043768" @default.
- W2765206989 hasPublicationYear "2017" @default.
- W2765206989 type Work @default.
- W2765206989 sameAs 2765206989 @default.
- W2765206989 citedByCount "14" @default.
- W2765206989 countsByYear W27652069892018 @default.
- W2765206989 countsByYear W27652069892019 @default.
- W2765206989 countsByYear W27652069892020 @default.
- W2765206989 countsByYear W27652069892021 @default.
- W2765206989 crossrefType "journal-article" @default.
- W2765206989 hasAuthorship W2765206989A5005526290 @default.
- W2765206989 hasAuthorship W2765206989A5041527004 @default.
- W2765206989 hasAuthorship W2765206989A5043595820 @default.
- W2765206989 hasAuthorship W2765206989A5057853538 @default.
- W2765206989 hasAuthorship W2765206989A5066621039 @default.
- W2765206989 hasAuthorship W2765206989A5068871940 @default.
- W2765206989 hasAuthorship W2765206989A5074506044 @default.
- W2765206989 hasAuthorship W2765206989A5078738161 @default.
- W2765206989 hasAuthorship W2765206989A5088343134 @default.
- W2765206989 hasConcept C104317684 @default.
- W2765206989 hasConcept C107459253 @default.
- W2765206989 hasConcept C145103041 @default.
- W2765206989 hasConcept C159047783 @default.
- W2765206989 hasConcept C22070199 @default.
- W2765206989 hasConcept C2522874641 @default.
- W2765206989 hasConcept C2776438120 @default.
- W2765206989 hasConcept C2777053367 @default.
- W2765206989 hasConcept C2777888124 @default.
- W2765206989 hasConcept C2778097271 @default.
- W2765206989 hasConcept C2778199166 @default.
- W2765206989 hasConcept C2778814567 @default.
- W2765206989 hasConcept C2779120600 @default.
- W2765206989 hasConcept C54355233 @default.
- W2765206989 hasConcept C86803240 @default.
- W2765206989 hasConceptScore W2765206989C104317684 @default.