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- W2765217275 abstract "2366 We have performed oligonucleotide array analysis on benzopyrene (B[a]P) induced lung tumors and similar tumors treated with the glucocorticoid budesonide using Affymetrix U74Av2 GeneChips in order to determine gene expression changes associated with budesonide treatment during lung tumorigenesis. Analysis yielded 363 genes with altered expression when comparing control lung tumors and tumors treated with budesonide. 243 genes are overexpressed and 120 genes are underexpressed after budesonide treatment. In addition, 108 genes which were differentially expressed between mouse lung tumors and normal lung parenchyma (50 genes overexpressed and 58 genes underexpressed) were found to be modulated back towards normal levels in budesonide treated tumors. These genes are involved in a broad range of different pathways including control of cell proliferation, differentiation, cell cycle, signal transduction, and apoptosis. Using the pathway visualization tool GenMapp, at least four regulatory pathways were found to contain clusters of differentially expressed genes: Wnt signaling, G protein pathway, MAPK cascade and Apoptosis. Overall, we have determined, for the first time, the expression profiles of genes modulated by budesonide during murine lung tumorigenesis. Our results suggest that budesonide exerts its chemopreventive and/or chemotherapeutic efficacy during mouse lung tumorigenesis through induction and/or inhibition of certain genes and to some degree to revert the expression of some genes to normal levels. Pluripotent effects of budesonide on many signal pathways involving multiple transcription factors and signaling molecules is considered to play a very important role in budesonide chemopreventive/chemotherapeutic effects in mouse lung tumorigenesis. Certain of these changes might serve as potential biomarkers in Phase II trials of budesonide in humans." @default.
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- W2765217275 date "2004-04-01" @default.
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- W2765217275 title "Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions." @default.
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