FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765220105> ?p ?o ?g. }

• W2765220105 endingPage "11514" @default.
• W2765220105 startingPage "11495" @default.
• W2765220105 abstract "The post-genomic era has provided researchers with a deluge of protein sequences. However, a significant fraction of the proteins encoded by sequenced genomes remains without an identified function. Here, we aim at determining how many enzymes of uncertain or unknown function are still present in the Saccharomyces cerevisiae and human proteomes. Using information available in the Swiss-Prot, BRENDA and KEGG databases in combination with a Hidden Markov Model-based method, we estimate that >600 yeast and 2000 human proteins (>30% of their proteins of unknown function) are enzymes whose precise function(s) remain(s) to be determined. This illustrates the impressive scale of the ‘unknown enzyme problem’. We extensively review classical biochemical as well as more recent systematic experimental and computational approaches that can be used to support enzyme function discovery research. Finally, we discuss the possible roles of the elusive catalysts in light of recent developments in the fields of enzymology and metabolism as well as the significance of the unknown enzyme problem in the context of metabolic modeling, metabolic engineering and rare disease research." @default.
• W2765220105 created "2017-11-10" @default.
• W2765220105 creator A5039603957 @default.
• W2765220105 creator A5046204389 @default.
• W2765220105 creator A5047309427 @default.
• W2765220105 creator A5057437092 @default.
• W2765220105 creator A5073358487 @default.
• W2765220105 creator A5088017410 @default.
• W2765220105 date "2017-10-20" @default.
• W2765220105 modified "2023-09-29" @default.
• W2765220105 title "Confronting the catalytic dark matter encoded by sequenced genomes" @default.
• W2765220105 cites W109269349 @default.
• W2765220105 cites W1513416624 @default.
• W2765220105 cites W1561252486 @default.
• W2765220105 cites W1579430094 @default.
• W2765220105 cites W1580280659 @default.
• W2765220105 cites W1722029454 @default.
• W2765220105 cites W1894936704 @default.
• W2765220105 cites W1914762032 @default.
• W2765220105 cites W1939931704 @default.
• W2765220105 cites W1951363514 @default.
• W2765220105 cites W1952732684 @default.
• W2765220105 cites W1952812303 @default.
• W2765220105 cites W1967496291 @default.
• W2765220105 cites W1970114563 @default.
• W2765220105 cites W1972897978 @default.
• W2765220105 cites W1973829984 @default.
• W2765220105 cites W1974635502 @default.
• W2765220105 cites W1975556592 @default.
• W2765220105 cites W1979514665 @default.
• W2765220105 cites W1982588489 @default.
• W2765220105 cites W1983748245 @default.
• W2765220105 cites W1985468934 @default.
• W2765220105 cites W1985756920 @default.
• W2765220105 cites W1987724491 @default.
• W2765220105 cites W1990456200 @default.
• W2765220105 cites W1992501047 @default.
• W2765220105 cites W1995117714 @default.
• W2765220105 cites W1995164611 @default.
• W2765220105 cites W1999888532 @default.
• W2765220105 cites W2003180508 @default.
• W2765220105 cites W2009453630 @default.
• W2765220105 cites W2010632526 @default.
• W2765220105 cites W2011577679 @default.
• W2765220105 cites W2016679879 @default.
• W2765220105 cites W2016950608 @default.
• W2765220105 cites W2017930303 @default.
• W2765220105 cites W2024038403 @default.
• W2765220105 cites W2024088832 @default.
• W2765220105 cites W2026708376 @default.
• W2765220105 cites W2028161249 @default.
• W2765220105 cites W2030474642 @default.
• W2765220105 cites W2036083342 @default.
• W2765220105 cites W2041063545 @default.
• W2765220105 cites W2041074211 @default.
• W2765220105 cites W2042221984 @default.
• W2765220105 cites W2042815880 @default.
• W2765220105 cites W2046301798 @default.
• W2765220105 cites W2046527060 @default.
• W2765220105 cites W2048458820 @default.
• W2765220105 cites W2050841641 @default.
• W2765220105 cites W2051554319 @default.
• W2765220105 cites W2055043387 @default.
• W2765220105 cites W2055212957 @default.
• W2765220105 cites W2055531830 @default.
• W2765220105 cites W2057862944 @default.
• W2765220105 cites W2060797027 @default.
• W2765220105 cites W2062539125 @default.
• W2765220105 cites W2063138197 @default.
• W2765220105 cites W2064437293 @default.
• W2765220105 cites W2065153938 @default.
• W2765220105 cites W2065181342 @default.
• W2765220105 cites W2065198029 @default.
• W2765220105 cites W2067776505 @default.
• W2765220105 cites W2068526246 @default.
• W2765220105 cites W2070818602 @default.
• W2765220105 cites W2072642274 @default.
• W2765220105 cites W2073580285 @default.
• W2765220105 cites W2073837631 @default.
• W2765220105 cites W2075220000 @default.
• W2765220105 cites W2078280087 @default.
• W2765220105 cites W2078365946 @default.
• W2765220105 cites W2079048673 @default.
• W2765220105 cites W2081505294 @default.
• W2765220105 cites W2082418604 @default.
• W2765220105 cites W2085176241 @default.
• W2765220105 cites W2090974720 @default.
• W2765220105 cites W2092199526 @default.
• W2765220105 cites W2093200425 @default.
• W2765220105 cites W2096093282 @default.
• W2765220105 cites W2096173332 @default.
• W2765220105 cites W2098174226 @default.
• W2765220105 cites W2099271904 @default.
• W2765220105 cites W2099842423 @default.
• W2765220105 cites W2103601429 @default.
• W2765220105 cites W2107459209 @default.
• W2765220105 cites W2107644337 @default.
• W2765220105 cites W2110256992 @default.

• next