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• W2765221341 abstract "Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated thermogenesis, the role of adiponectin in thermogenesis is not clear. In this study, we investigated the role of adiponectin in thermogenesis using adiponectin-null mice (Adipoq −/−). Body composition was measured using EchoMRI. Metabolic parameters were determined by indirect calorimetry. Insulin sensitivity was evaluated by glucose- and insulin- tolerance tests. Core body temperature was measured by a TH-8 temperature monitoring system. Gene expression was assessed by real-time PCR and protein levels were analyzed by Western blotting and immunohistochemistry. The mitochondrial density of brown adipose tissue was quantified by calculating the ratio of mtDNA:total nuclear DNA. Under normal housing temperature of 24 °C and ad libitum feeding condition, the body weight, body composition, and metabolic profile of Adipoq −/− mice were unchanged. Under fasting condition, Adipoq −/− mice exhibited reduced energy expenditure. Conversely, under cold exposure, Adipoq −/− mice exhibited reduced body temperature, and the expression of thermogenic regulatory genes was significantly reduced in brown adipose tissue (BAT) and subcutaneous white adipose tissue (WAT). Moreover, we observed that mitochondrial content was reduced in BAT and subcutaneous WAT, and the expression of mitochondrial fusion genes was decreased in BAT of Adipoq −/− mice, suggesting that adiponectin ablation diminishes mitochondrial biogenesis and altered mitochondrial dynamics. Our study further revealed that adiponectin deletion suppresses adrenergic activation, and down-regulates β3-adrenergic receptor, insulin signaling, and the AMPK-SIRT1 pathway in BAT. Our findings demonstrate that adiponectin is an essential regulator of thermogenesis, and adiponectin is required for maintaining body temperature under cold exposure." @default.
• W2765221341 created "2017-11-10" @default.
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• W2765221341 date "2017-10-23" @default.
• W2765221341 modified "2023-09-26" @default.
• W2765221341 title "Adiponectin is required for maintaining normal body temperature in a cold environment" @default.
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• W2765221341 cites W1976095508 @default.
• W2765221341 cites W1977188464 @default.
• W2765221341 cites W1980515679 @default.
• W2765221341 cites W1981261500 @default.
• W2765221341 cites W1993132387 @default.
• W2765221341 cites W1996271362 @default.
• W2765221341 cites W1996296770 @default.
• W2765221341 cites W1997585716 @default.
• W2765221341 cites W2009190806 @default.
• W2765221341 cites W2014654113 @default.
• W2765221341 cites W2018019380 @default.
• W2765221341 cites W2019455536 @default.
• W2765221341 cites W2024045979 @default.
• W2765221341 cites W2027753197 @default.
• W2765221341 cites W2032065353 @default.
• W2765221341 cites W2032234589 @default.
• W2765221341 cites W2033100201 @default.
• W2765221341 cites W2034757478 @default.
• W2765221341 cites W2043419594 @default.
• W2765221341 cites W2044489647 @default.
• W2765221341 cites W2046642142 @default.
• W2765221341 cites W2049965571 @default.
• W2765221341 cites W2050132057 @default.
• W2765221341 cites W2055928731 @default.
• W2765221341 cites W2060508200 @default.
• W2765221341 cites W2075282827 @default.
• W2765221341 cites W2077228450 @default.
• W2765221341 cites W2094693749 @default.
• W2765221341 cites W2098373558 @default.
• W2765221341 cites W2099655870 @default.
• W2765221341 cites W2103533003 @default.
• W2765221341 cites W2104645520 @default.
• W2765221341 cites W2114821999 @default.
• W2765221341 cites W2115466888 @default.
• W2765221341 cites W2118737586 @default.
• W2765221341 cites W2125367015 @default.
• W2765221341 cites W2127293652 @default.
• W2765221341 cites W2127653983 @default.
• W2765221341 cites W2127806759 @default.
• W2765221341 cites W2127831042 @default.
• W2765221341 cites W2130825771 @default.
• W2765221341 cites W2132358997 @default.
• W2765221341 cites W2132388042 @default.
• W2765221341 cites W2136070507 @default.
• W2765221341 cites W2140312503 @default.
• W2765221341 cites W2154358935 @default.
• W2765221341 cites W2156101934 @default.
• W2765221341 cites W2156548171 @default.
• W2765221341 cites W2167362732 @default.
• W2765221341 cites W2176573833 @default.
• W2765221341 cites W2205941849 @default.
• W2765221341 cites W2346315565 @default.
• W2765221341 cites W2359450119 @default.
• W2765221341 cites W2403047053 @default.
• W2765221341 cites W2412319288 @default.
• W2765221341 cites W2416003725 @default.
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• W2765221341 cites W2583256732 @default.
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• W2765221341 doi "https://doi.org/10.1186/s12899-017-0034-7" @default.
• W2765221341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5651620" @default.
• W2765221341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29058611" @default.
• W2765221341 hasPublicationYear "2017" @default.
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