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- W2765226490 abstract "Paricalcitol is a synthetic vitamin D receptor agonist licensed to treat secondary hyperparathyroidism, which was found to be nephroprotective in preclinical studies. 1 Pérez-Gómez MV Ortiz-Arduan A Lorenzo-Sellares V Vitamin D and proteinuria: a critical review of molecular bases and clinical experience. Nefrologia. 2013; 33: 716-726 PubMed Google Scholar In the VITAL clinical trial, 2 de Zeeuw D Agarwal R Amdahl M et al. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet. 2010; 376: 1543-1551 Summary Full Text Full Text PDF PubMed Scopus (599) Google Scholar the investigators reported that addition of 2 μg per day paricalcitol to renin–angiotensin system blockade safely lowered residual albuminuria in patients with diabetic nephropathy. However, in a post-hoc analysis, benefit was limited to patients with a high salt intake. Moderate salt restriction with or without paricalcitol in type 2 diabetes and losartan-resistant macroalbuminuria (PROCEED): a randomised, double-blind, placebo-controlled, crossover trialIn patients with macroalbuminuria and type 2 diabetes, moderate salt restriction enhances the antialbuminuric effect of losartan, an effect that could be nephroprotective and cardioprotective in the long term. The finding that paricalcitol prevents a sodium-induced increase in albuminuria provides support for trials to test the long-term risk-benefit profile of paricalcitol add-on therapy in patients with type 2 diabetes and macroalbuminuria refractory to dietary salt restriction, including patients refractory to even moderate salt restriction. Full-Text PDF" @default.
- W2765226490 created "2017-11-10" @default.
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- W2765226490 date "2018-01-01" @default.
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- W2765226490 title "Paricalcitol and albuminuria: tread carefully" @default.
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- W2765226490 doi "https://doi.org/10.1016/s2213-8587(17)30361-3" @default.
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