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- W2765227482 abstract "Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1–32 were synthesized and characterized by 1HNMR, 13CNNMR and HREI-MS. All compounds were evaluated in vitro for β-glucuronidase inhibitory potential. All analogs showed varying degree of β-glucuronidase inhibitory potential ranging from 0.10 ± 0.01 to 48.50 ± 1.10 μM when compared with the standard drug d-saccharic acid-1,4-lactone (IC50 value 48.30 ± 1.20 μM). Derivatives 1–32 showed the highest β-glucuronidase inhibitory potentials which is many folds better than the standard drug d-saccharic acid-1,4-lactone. Further molecular docking study validated the experimental results. It was proposed that bis-indolylmethane may interact with some amino acid residues located within the active site of β-glucuronidase enzyme. This study has culminated in the identification of a new class of potent β-glucuronidase inhibitors." @default.
- W2765227482 created "2017-11-10" @default.
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- W2765227482 date "2018-01-01" @default.
- W2765227482 modified "2023-10-15" @default.
- W2765227482 title "Synthesis of bis-indolylmethanes as new potential inhibitors of β-glucuronidase and their molecular docking studies" @default.
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- W2765227482 doi "https://doi.org/10.1016/j.ejmech.2017.10.071" @default.
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