Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765257485> ?p ?o ?g. }
- W2765257485 endingPage "3394" @default.
- W2765257485 startingPage "3386" @default.
- W2765257485 abstract "The self-assembling peptides Ac-(RADA)4-CONH2 and Ac-(IEIK)3I-CONH2, which form hydrogels in physiological conditions, were evaluated as carriers for ocular delivery of the β-blocker timolol maleate. Electron microscopy studies revealed that hydrogels contain nanofibers, whereas rheological studies showed that the Ac-(IEIK)3I-CONH2 self-assembles in a stiffer hydrogel compared with the Ac-(RADA)4-CONH2 peptide. The in vitro release and ex vivo permeation studies demonstrated controlled release and transport of the drug through the cornea, which depended on the self-assembling peptide sequence. In vivo studies in rabbits showed significant increase in the area under the concentration–time curve (AUC) after administration of the drug through the Ac-(RADA)4-CONH2 hydrogel compared to drug solution, whereas a sustained reduction of intraocular pressure for up to 24 h after instillation was achieved for both drug-loaded hydrogels. Histological studies revealed good ocular tolerability upon application of the formulations, suggesting that self-assembling peptide hydrogels are promising systems for sustained ocular drug delivery." @default.
- W2765257485 created "2017-11-10" @default.
- W2765257485 creator A5004541097 @default.
- W2765257485 creator A5016741183 @default.
- W2765257485 creator A5033343314 @default.
- W2765257485 creator A5042760783 @default.
- W2765257485 creator A5055611807 @default.
- W2765257485 creator A5076243773 @default.
- W2765257485 creator A5082613480 @default.
- W2765257485 creator A5091628026 @default.
- W2765257485 date "2017-11-16" @default.
- W2765257485 modified "2023-10-01" @default.
- W2765257485 title "Self-Assembling Peptide Nanofiber Hydrogels for Controlled Ocular Delivery of Timolol Maleate" @default.
- W2765257485 cites W1539059023 @default.
- W2765257485 cites W1546424151 @default.
- W2765257485 cites W1969453607 @default.
- W2765257485 cites W1975463230 @default.
- W2765257485 cites W1979425595 @default.
- W2765257485 cites W1979565474 @default.
- W2765257485 cites W1986305195 @default.
- W2765257485 cites W1996155302 @default.
- W2765257485 cites W2001041074 @default.
- W2765257485 cites W2002128115 @default.
- W2765257485 cites W2006438089 @default.
- W2765257485 cites W2007802748 @default.
- W2765257485 cites W2012774822 @default.
- W2765257485 cites W2021513083 @default.
- W2765257485 cites W2023954079 @default.
- W2765257485 cites W2026780757 @default.
- W2765257485 cites W2027581523 @default.
- W2765257485 cites W2030966135 @default.
- W2765257485 cites W2043507378 @default.
- W2765257485 cites W2046264407 @default.
- W2765257485 cites W2050936212 @default.
- W2765257485 cites W2071746665 @default.
- W2765257485 cites W2074208432 @default.
- W2765257485 cites W2080810229 @default.
- W2765257485 cites W2099014215 @default.
- W2765257485 cites W2115305419 @default.
- W2765257485 cites W2116704983 @default.
- W2765257485 cites W2122483230 @default.
- W2765257485 cites W2126691225 @default.
- W2765257485 cites W2150449993 @default.
- W2765257485 cites W2161168513 @default.
- W2765257485 cites W2171271556 @default.
- W2765257485 cites W2192639736 @default.
- W2765257485 cites W2208351504 @default.
- W2765257485 cites W2626182649 @default.
- W2765257485 cites W2755947245 @default.
- W2765257485 cites W364542823 @default.
- W2765257485 cites W4249939336 @default.
- W2765257485 doi "https://doi.org/10.1021/acsbiomaterials.7b00706" @default.
- W2765257485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33445378" @default.
- W2765257485 hasPublicationYear "2017" @default.
- W2765257485 type Work @default.
- W2765257485 sameAs 2765257485 @default.
- W2765257485 citedByCount "33" @default.
- W2765257485 countsByYear W27652574852018 @default.
- W2765257485 countsByYear W27652574852019 @default.
- W2765257485 countsByYear W27652574852020 @default.
- W2765257485 countsByYear W27652574852021 @default.
- W2765257485 countsByYear W27652574852022 @default.
- W2765257485 countsByYear W27652574852023 @default.
- W2765257485 crossrefType "journal-article" @default.
- W2765257485 hasAuthorship W2765257485A5004541097 @default.
- W2765257485 hasAuthorship W2765257485A5016741183 @default.
- W2765257485 hasAuthorship W2765257485A5033343314 @default.
- W2765257485 hasAuthorship W2765257485A5042760783 @default.
- W2765257485 hasAuthorship W2765257485A5055611807 @default.
- W2765257485 hasAuthorship W2765257485A5076243773 @default.
- W2765257485 hasAuthorship W2765257485A5082613480 @default.
- W2765257485 hasAuthorship W2765257485A5091628026 @default.
- W2765257485 hasBestOaLocation W27652574852 @default.
- W2765257485 hasConcept C108586683 @default.
- W2765257485 hasConcept C118487528 @default.
- W2765257485 hasConcept C136229726 @default.
- W2765257485 hasConcept C150903083 @default.
- W2765257485 hasConcept C171250308 @default.
- W2765257485 hasConcept C185592680 @default.
- W2765257485 hasConcept C188027245 @default.
- W2765257485 hasConcept C192562407 @default.
- W2765257485 hasConcept C202751555 @default.
- W2765257485 hasConcept C207001950 @default.
- W2765257485 hasConcept C26291073 @default.
- W2765257485 hasConcept C2776882836 @default.
- W2765257485 hasConcept C2779281246 @default.
- W2765257485 hasConcept C2779560670 @default.
- W2765257485 hasConcept C2779820397 @default.
- W2765257485 hasConcept C55493867 @default.
- W2765257485 hasConcept C71924100 @default.
- W2765257485 hasConcept C86803240 @default.
- W2765257485 hasConcept C91129048 @default.
- W2765257485 hasConcept C98274493 @default.
- W2765257485 hasConceptScore W2765257485C108586683 @default.
- W2765257485 hasConceptScore W2765257485C118487528 @default.
- W2765257485 hasConceptScore W2765257485C136229726 @default.
- W2765257485 hasConceptScore W2765257485C150903083 @default.
- W2765257485 hasConceptScore W2765257485C171250308 @default.