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- W2765264352 endingPage "2905" @default.
- W2765264352 startingPage "2888" @default.
- W2765264352 abstract "Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to reach the brain in a non-invasive way. This article is a comprehensive review of the state-of-the-art of this emerging peptide delivery route, as well as of the challenges associated to it. Emphasis is given on the potential of nanosized drug delivery carriers to enhance the direct N-to-B transport of protein or peptide drugs. In particular, polymer- and lipid- based nanocarriers are comparatively analyzed in terms of the influence of their physicochemical characteristics and composition on their in vivo fate and efficacy. The use of biorecognitive ligands and permeation enhancers in order to enhance their brain targeting efficiency is also discussed. The article concludes highlighting the early stage of this research field and its still unveiled potential. The final message is that more explicatory PK/PD studies are required in order to achieve the translation from preclinical to the clinical development phase." @default.
- W2765264352 created "2017-11-10" @default.
- W2765264352 creator A5031298057 @default.
- W2765264352 creator A5072428823 @default.
- W2765264352 date "2018-06-01" @default.
- W2765264352 modified "2023-10-12" @default.
- W2765264352 title "Nose-to-brain peptide delivery – The potential of nanotechnology" @default.
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