Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765282239> ?p ?o ?g. }
- W2765282239 endingPage "469" @default.
- W2765282239 startingPage "461" @default.
- W2765282239 abstract "Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and oxidative modification of plasma proteins are known to occur under hyperglycemia and oxidative stress. In this study, shotgun proteomics and 2H2O-based metabolic labeling were used to characterize post-translational modifications and assess the kinetics of Trf and Cp in T2DM patients and matched controls in vivo. Six early lysine (Amadori) and one advanced arginine glycation were detected in Trf. No glycation, but five asparagine deamidations, were found in Cp. T2DM patients had increased fractional catabolic rates of both Trf and Cp that correlated with HbA1c (p < 0.05). The glycated Trf population was subject to an even faster degradation compared to the total Trf pool, suggesting that hyperglycemia contributed to an increased Trf degradation in T2DM patients. Enhanced production of Trf and Cp kept their levels stable. The changes in Trf and Cp turnover were associated with increased systemic oxidative stress without any alteration in iron status in T2DM. These findings can help better understand the potential role of altered Trf and Cp metabolism in the pathogenesis of T2DM and other diseases." @default.
- W2765282239 created "2017-11-10" @default.
- W2765282239 creator A5003236350 @default.
- W2765282239 creator A5004361135 @default.
- W2765282239 creator A5008745523 @default.
- W2765282239 creator A5047453618 @default.
- W2765282239 creator A5060210855 @default.
- W2765282239 creator A5060425938 @default.
- W2765282239 creator A5066614378 @default.
- W2765282239 creator A5087950841 @default.
- W2765282239 date "2017-12-01" @default.
- W2765282239 modified "2023-10-16" @default.
- W2765282239 title "Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes" @default.
- W2765282239 cites W166701849 @default.
- W2765282239 cites W1735966469 @default.
- W2765282239 cites W1898588072 @default.
- W2765282239 cites W1972740065 @default.
- W2765282239 cites W1973525483 @default.
- W2765282239 cites W1976913734 @default.
- W2765282239 cites W1981569438 @default.
- W2765282239 cites W1986298394 @default.
- W2765282239 cites W1993932776 @default.
- W2765282239 cites W1998198134 @default.
- W2765282239 cites W1999087731 @default.
- W2765282239 cites W2004067151 @default.
- W2765282239 cites W2017947908 @default.
- W2765282239 cites W2023010129 @default.
- W2765282239 cites W2031140597 @default.
- W2765282239 cites W2032496710 @default.
- W2765282239 cites W2036528562 @default.
- W2765282239 cites W2044248130 @default.
- W2765282239 cites W2048124973 @default.
- W2765282239 cites W2050574817 @default.
- W2765282239 cites W2054394892 @default.
- W2765282239 cites W2059164805 @default.
- W2765282239 cites W2063869708 @default.
- W2765282239 cites W2068608108 @default.
- W2765282239 cites W2072829138 @default.
- W2765282239 cites W2079952067 @default.
- W2765282239 cites W2080752012 @default.
- W2765282239 cites W2085039467 @default.
- W2765282239 cites W2086464243 @default.
- W2765282239 cites W2088567476 @default.
- W2765282239 cites W2104391291 @default.
- W2765282239 cites W2106601510 @default.
- W2765282239 cites W2109673760 @default.
- W2765282239 cites W2109804618 @default.
- W2765282239 cites W2111697619 @default.
- W2765282239 cites W2119154675 @default.
- W2765282239 cites W2131184459 @default.
- W2765282239 cites W2134730662 @default.
- W2765282239 cites W2134830538 @default.
- W2765282239 cites W2135581618 @default.
- W2765282239 cites W2145398446 @default.
- W2765282239 cites W2152102707 @default.
- W2765282239 cites W2154746915 @default.
- W2765282239 cites W2158563866 @default.
- W2765282239 cites W2161381003 @default.
- W2765282239 cites W2162068355 @default.
- W2765282239 cites W2163236262 @default.
- W2765282239 cites W2166713613 @default.
- W2765282239 cites W2167258993 @default.
- W2765282239 cites W2327421263 @default.
- W2765282239 cites W2336550165 @default.
- W2765282239 cites W2406984260 @default.
- W2765282239 cites W2465342280 @default.
- W2765282239 cites W2489679847 @default.
- W2765282239 cites W2504666801 @default.
- W2765282239 cites W2966185142 @default.
- W2765282239 doi "https://doi.org/10.1016/j.freeradbiomed.2017.10.373" @default.
- W2765282239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5739305" @default.
- W2765282239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29079528" @default.
- W2765282239 hasPublicationYear "2017" @default.
- W2765282239 type Work @default.
- W2765282239 sameAs 2765282239 @default.
- W2765282239 citedByCount "36" @default.
- W2765282239 countsByYear W27652822392018 @default.
- W2765282239 countsByYear W27652822392019 @default.
- W2765282239 countsByYear W27652822392020 @default.
- W2765282239 countsByYear W27652822392021 @default.
- W2765282239 countsByYear W27652822392022 @default.
- W2765282239 countsByYear W27652822392023 @default.
- W2765282239 crossrefType "journal-article" @default.
- W2765282239 hasAuthorship W2765282239A5003236350 @default.
- W2765282239 hasAuthorship W2765282239A5004361135 @default.
- W2765282239 hasAuthorship W2765282239A5008745523 @default.
- W2765282239 hasAuthorship W2765282239A5047453618 @default.
- W2765282239 hasAuthorship W2765282239A5060210855 @default.
- W2765282239 hasAuthorship W2765282239A5060425938 @default.
- W2765282239 hasAuthorship W2765282239A5066614378 @default.
- W2765282239 hasAuthorship W2765282239A5087950841 @default.
- W2765282239 hasBestOaLocation W27652822392 @default.
- W2765282239 hasConcept C126322002 @default.
- W2765282239 hasConcept C134018914 @default.
- W2765282239 hasConcept C147990577 @default.
- W2765282239 hasConcept C185592680 @default.
- W2765282239 hasConcept C195580219 @default.
- W2765282239 hasConcept C22814914 @default.