FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765283007> ?p ?o ?g. }

• W2765283007 abstract "Abstract Background Perinatal transmission is the main route of hepatitis B virus (HBV) transmission. While several measures have been attempted as means of preventing perinatal HBV transmission, the optimal strategy remains inconclusive. Methods We conducted a comprehensive search, through December 2016, for randomized controlled trials (RCTs) that compared the following measures among pregnant women with HBV infection: placebo/none, active immunoprophylaxis (hepatitis B vaccine series starting at birth [HBVac]), passive-active immunoprophylaxis (hepatitis B immunoglobulin and vaccine [HBIG+HBVac]), prenatal HBIG administration (HBIG/HBIG+HBVac), and prenatal antiviral therapy (AVT/HBIG+HBVac). Direct, indirect, and network meta-analyses were performed for all treatment comparisons. Results Fifteen RCTs involving 2706 infants of HBV carrier mothers were eligible for analysis. Network meta-analysis demonstrated similar results as direct and indirect comparisons. HBVac alone significantly reduced the risk of hepatitis B infection in infants of HBV carrier mothers (relative risk [RR], 0.32; 95% confidence interval [CI], 0.21–0.50). The combination of immunoglobulin with vaccine is superior to vaccine alone (RR, 0.37; 95% CI, 0.20–0.67). Prenatal HBIG administration and antiviral therapy offer further advantages over current passive-active immunoprophylaxis for infants of highly viremic (HBV DNA level higher than 2 × 105 IU/mL) mothers (RR, 0.47; 95% CI, 0.29–0.75; and RR, 0.31; 95% CI, 0.10–0.99, respectively). There was no significant publication bias. Conclusions Based on the universal infantile vaccination program, HBIG for infants born to HBV carrier mothers further reduces transmission. For highly viremic mothers whose children are still at risk for transmission under current immunoprophylaxis, prenatal HBIG administration or antiviral therapy in late pregnancy may be considered if more long-term evidence supports its efficacy and safety." @default.
• W2765283007 created "2017-11-10" @default.
• W2765283007 creator A5013705740 @default.
• W2765283007 creator A5021550676 @default.
• W2765283007 creator A5029561060 @default.
• W2765283007 creator A5042355254 @default.
• W2765283007 creator A5060571206 @default.
• W2765283007 creator A5060665430 @default.
• W2765283007 creator A5060882272 @default.
• W2765283007 date "2017-01-01" @default.
• W2765283007 modified "2023-10-12" @default.
• W2765283007 title "Comparative Effectiveness of Prophylactic Strategies for Perinatal Transmission of Hepatitis B Virus: A Network Meta-analysis of Randomized Controlled Trials" @default.
• W2765283007 cites W129225670 @default.
• W2765283007 cites W1480729244 @default.
• W2765283007 cites W1560139616 @default.
• W2765283007 cites W1599401828 @default.
• W2765283007 cites W1601526283 @default.
• W2765283007 cites W194160568 @default.
• W2765283007 cites W1964922930 @default.
• W2765283007 cites W1982481845 @default.
• W2765283007 cites W1986215651 @default.
• W2765283007 cites W1995673687 @default.
• W2765283007 cites W2002352706 @default.
• W2765283007 cites W2007951262 @default.
• W2765283007 cites W2018346982 @default.
• W2765283007 cites W2030305892 @default.
• W2765283007 cites W2038693293 @default.
• W2765283007 cites W2039128720 @default.
• W2765283007 cites W2067769032 @default.
• W2765283007 cites W2101122742 @default.
• W2765283007 cites W2105585202 @default.
• W2765283007 cites W2124106198 @default.
• W2765283007 cites W2131192419 @default.
• W2765283007 cites W2136043981 @default.
• W2765283007 cites W2139660365 @default.
• W2765283007 cites W2173274566 @default.
• W2765283007 cites W2173698250 @default.
• W2765283007 cites W2227353608 @default.
• W2765283007 cites W2343638017 @default.
• W2765283007 cites W2360057192 @default.
• W2765283007 cites W2410694412 @default.
• W2765283007 cites W2411561091 @default.
• W2765283007 cites W2415227587 @default.
• W2765283007 cites W2415231638 @default.
• W2765283007 cites W2442031947 @default.
• W2765283007 cites W2618139062 @default.
• W2765283007 cites W4243747196 @default.
• W2765283007 cites W4301878768 @default.
• W2765283007 cites W853460 @default.
• W2765283007 doi "https://doi.org/10.1093/ofid/ofx225" @default.
• W2765283007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5695632" @default.
• W2765283007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29181424" @default.
• W2765283007 hasPublicationYear "2017" @default.
• W2765283007 type Work @default.
• W2765283007 sameAs 2765283007 @default.
• W2765283007 citedByCount "7" @default.
• W2765283007 countsByYear W27652830072018 @default.
• W2765283007 countsByYear W27652830072020 @default.
• W2765283007 countsByYear W27652830072021 @default.
• W2765283007 countsByYear W27652830072022 @default.
• W2765283007 countsByYear W27652830072023 @default.
• W2765283007 crossrefType "journal-article" @default.
• W2765283007 hasAuthorship W2765283007A5013705740 @default.
• W2765283007 hasAuthorship W2765283007A5021550676 @default.
• W2765283007 hasAuthorship W2765283007A5029561060 @default.
• W2765283007 hasAuthorship W2765283007A5042355254 @default.
• W2765283007 hasAuthorship W2765283007A5060571206 @default.
• W2765283007 hasAuthorship W2765283007A5060665430 @default.
• W2765283007 hasAuthorship W2765283007A5060882272 @default.
• W2765283007 hasBestOaLocation W27652830071 @default.
• W2765283007 hasConcept C119599485 @default.
• W2765283007 hasConcept C126322002 @default.
• W2765283007 hasConcept C127413603 @default.
• W2765283007 hasConcept C159047783 @default.
• W2765283007 hasConcept C168563851 @default.
• W2765283007 hasConcept C187212893 @default.
• W2765283007 hasConcept C203014093 @default.
• W2765283007 hasConcept C22070199 @default.
• W2765283007 hasConcept C2522874641 @default.
• W2765283007 hasConcept C2777382497 @default.
• W2765283007 hasConcept C2777410769 @default.
• W2765283007 hasConcept C2779234561 @default.
• W2765283007 hasConcept C2780593183 @default.
• W2765283007 hasConcept C2781037505 @default.
• W2765283007 hasConcept C44249647 @default.
• W2765283007 hasConcept C54355233 @default.
• W2765283007 hasConcept C71924100 @default.
• W2765283007 hasConcept C761482 @default.
• W2765283007 hasConcept C82789193 @default.
• W2765283007 hasConcept C86803240 @default.
• W2765283007 hasConcept C95190672 @default.
• W2765283007 hasConceptScore W2765283007C119599485 @default.
• W2765283007 hasConceptScore W2765283007C126322002 @default.
• W2765283007 hasConceptScore W2765283007C127413603 @default.
• W2765283007 hasConceptScore W2765283007C159047783 @default.
• W2765283007 hasConceptScore W2765283007C168563851 @default.
• W2765283007 hasConceptScore W2765283007C187212893 @default.
• W2765283007 hasConceptScore W2765283007C203014093 @default.
• W2765283007 hasConceptScore W2765283007C22070199 @default.
• W2765283007 hasConceptScore W2765283007C2522874641 @default.

• next