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• W2765286032 abstract "These are exciting times in the development of therapeutics for cystic fibrosis (CF). New correctors and potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) are being developed in academic laboratories and pharmaceutical companies, and the field is just beginning to understand their mechanisms of action. Studies of CFTR modulators are also yielding insight into the general principles and strategies that can be used when developing pharmacological chaperones, a new class of drugs. Combining two or even three correctors with a potentiator is an especially promising approach which should lead to further improvements in efficacy and clinical benefit for patients." @default.
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• W2765286032 date "2017-06-01" @default.
• W2765286032 modified "2023-09-24" @default.
• W2765286032 title "Corrector combination therapies for F508del-CFTR" @default.
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• W2765286032 doi "https://doi.org/10.1016/j.coph.2017.09.016" @default.
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