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- W2765289022 abstract "OmpR, a protein that regulates expression of outer membrane porin proteins in enteric bacteria, belongs to a large family of transcription factors. These transcription factors bind DNA and interact productively with RNA polymerase to activate transcription. The two functions, DNA-binding and transcriptional activation, have been localized within the 100 amino acid DNA-binding domain that characterizes members of the OmpR family. Both DNA binding and transcriptional activation by OmpR related proteins have remained poorly understood for lack of structural information or lack of sequence homology with transcription factors of known three-dimensional structure. The recently determined crystal structures of the Escherichia coli OmpR DNA-binding domain (OmpRc) have defined a new subfamily of “winged-helix-turn-helix” DNA-binding proteins. Structural elements of OmpRc can be assigned functional roles by analogy to other winged-helix DNA-binding proteins. A structure based sequence analysis of the OmpR family of transcription factors indicates specific roles for all conserved amino acid residues. Mutagenesis studies performed on several members of this family, OmpR, PhoB, ToxR and VirG, can now be interpreted with respect to the structure." @default.
- W2765289022 created "2017-11-10" @default.
- W2765289022 creator A5039365328 @default.
- W2765289022 creator A5074597936 @default.
- W2765289022 date "1997-06-01" @default.
- W2765289022 modified "2023-10-18" @default.
- W2765289022 title "Structural relationships in the OmpR family of winged-helix transcription factors 1 1Edited by M. Gottesman" @default.
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- W2765289022 doi "https://doi.org/10.1006/jmbi.1997.1065" @default.
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