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• W2765324326 abstract "Neurologic disease is a common extraglandular manifestation of Sjögren's syndrome (SS), the study of which has been hampered both by the lack of uniform definitions for specific neurologic complications and by the imprecision of the tools used to diagnose SS. There is a great need to develop consensus criteria for classifying these varied neurologic manifestations, as has been done in systemic lupus erythematosus (SLE) Arthritis and rheumatism 42:599-608, 1999. SS patients with certain forms of neurologic involvement, such as small fiber neuropathy and sensory ataxic ganglionopathy, frequently lack anti-SSA and anti-SSB antibodies and other serologic abnormalities. In these patients, neurologic disease is often their presenting manifestation, triggering a search for underlying SS. Given the frequent seronegativity of such patients, their diagnosis of SS rests heavily on the interpretation of a labial gland biopsy. However, these biopsies are prone to misinterpretation Vivino etal. J Rheumatol 29:938-44, 2002, and positive ones are found in up to 15% of healthy volunteers Radfar et al. Arthrit Rheumatu 47:520-4, 2002. Better diagnostic tools are needed to determine if the frequent seronegative status of these SS patients may be related to a unique disease pathogenesis.Recent advances in diagnostic techniques have served to define a likely pathogenetic basis for certain neurologic manifestations of SS. The advent of punch skin biopsies to analyze intraepidermal nerve fiber density and morphology has helped define pure sensory small fiber neuropathy as common in SS and the basis for both length- and non-length-dependent patterns of neuropathic pain. New protocols for magnetic resonance imaging (MRI) have enabled the recognition of dorsal root ganglionitis, a finding originally detected in pathologic studies. The advent of the anti-aquaporin-4 (AQP4) antibody test in 2004 has Led to the appreciation that demyelinating disease in SS is often related to the presence of neuromyelitis optica spectrum disorder. The anti-AQP4 antibody is considered to be directly pathogenic in the brain, targeting the primary water channel proteins in the brain, expressed prominently on astrocytic foot processes.There are no clinical trials evaluating the efficacy of systemic immune suppressive therapy for peripheral or central nervous system involvement. With the recent increase in clinical trials of biologic agents for SS, which utilize systemic disease manifestations as standardized outcome measures, there is an urgency to deveLop appropriate definitions of neuroLogic compLications of SS and cLear parameters for clinical improvement." @default.
• W2765324326 created "2017-11-10" @default.
• W2765324326 creator A5018878859 @default.
• W2765324326 creator A5089493471 @default.
• W2765324326 date "2017-10-24" @default.
• W2765324326 modified "2023-10-09" @default.
• W2765324326 title "Neurological Complications of Sjögren’s Syndrome: Diagnosis and Management" @default.
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• W2765324326 doi "https://doi.org/10.1007/s40674-017-0076-9" @default.
• W2765324326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6322693" @default.
• W2765324326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30627507" @default.
• W2765324326 hasPublicationYear "2017" @default.

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