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- W2765331004 abstract "Cardiovascular diseases are the leading cause of death in the Western world. Unfortunately, current therapies are often only palliative, consequently essentially making heart transplantation necessary for many patients. However, several novel therapeutic approaches in the past two decades have yielded quite encouraging results. The generation of induced pluripotent stem cells, through the forced expression of stem cell-specific transcription factors, has inspired the most promising strategies for heart regeneration by direct reprogramming of cardiac fibroblasts into functional cardiomyocytes. Initial attempts at this reprogramming were conducted using a similar approach to the one used with transcription factors, but during years, novel strategies have been tested, e.g., miRNAs, recombinant proteins and chemical molecules. Although preliminary results on animal models are promising, the low reprogramming efficiency, as well as the incomplete maturation of the cardiomyocytes, still represents important obstacles. This review covers direct transdifferentiation strategies that have been proposed and developed and illustrates the pros and cons of each approach. Indeed, as described in the manuscript, there are still many unanswered questions and drawbacks that require a better understanding of the basic signaling pathways and transcription factor networks before functional cells, suitable for cardiac regeneration and safe for the patients, can be generated and used for human therapies." @default.
- W2765331004 created "2017-11-10" @default.
- W2765331004 creator A5021876600 @default.
- W2765331004 creator A5028702802 @default.
- W2765331004 creator A5031235255 @default.
- W2765331004 creator A5056388083 @default.
- W2765331004 creator A5076632691 @default.
- W2765331004 date "2017-10-27" @default.
- W2765331004 modified "2023-09-24" @default.
- W2765331004 title "Regenerating the human heart: direct reprogramming strategies and their current limitations" @default.
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- W2765331004 doi "https://doi.org/10.1007/s00395-017-0655-9" @default.
- W2765331004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29079873" @default.
- W2765331004 hasPublicationYear "2017" @default.
- W2765331004 type Work @default.