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- W2765352589 abstract "Compared to adult-onset schizophrenia, relatively few neuroimaging studies have examined functional connectivity (FC) abnormalities in adolescent-onset schizophrenia (AOS). The present study was designed to investigate resting-state interhemispheric connectivity patterns among drug-naive first-episode AOS patients and potential changes following short-term antipsychotic drug treatment.This study included 107 drug-naïve, first-episode AOS patients (age: 15.33 ± 1.62, 45 males) and 67 matched healthy controls (age: 15.43 ± 1.86, 30 males). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans, and 34 AOS patients (age: 15.12 ± 1.68, 12 males) also underwent a follow-up scan after 8 weeks of antipsychotic drug treatment. Interhemispheric functional connectivity was measured by voxel-mirrored homotopic connectivity (VMHC).Compared to healthy controls, AOS patients showed increased VMHC values in putamen and caudate. No significant differences were observed between the patients at baseline and after 8 weeks of treatment.First-episode, drug-naive AOS patients demonstrate abnormalities in interhemispheric FC, and these are not mitigated by short-term antipsychotic treatment." @default.
- W2765352589 created "2017-11-10" @default.
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- W2765352589 date "2018-05-01" @default.
- W2765352589 modified "2023-09-23" @default.
- W2765352589 title "Aberrant corticostriatal connectivity predict positive symptoms of antipsychotic-naïve patients with adolescent-onset schizophrenia during brain maturation" @default.
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- W2765352589 doi "https://doi.org/10.1016/j.schres.2017.10.025" @default.
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