Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765354611> ?p ?o ?g. }
- W2765354611 endingPage "1341" @default.
- W2765354611 startingPage "1332" @default.
- W2765354611 abstract "Live regulatory T cells (Treg cells) suppress antitumor immunity, but how Treg cells behave in the metabolically abnormal tumor microenvironment remains unknown. Here we show that tumor Treg cells undergo apoptosis, and such apoptotic Treg cells abolish spontaneous and PD-L1-blockade-mediated antitumor T cell immunity. Biochemical and functional analyses show that adenosine, but not typical suppressive factors such as PD-L1, CTLA-4, TGF-β, IL-35, and IL-10, contributes to apoptotic Treg-cell-mediated immunosuppression. Mechanistically, apoptotic Treg cells release and convert a large amount of ATP to adenosine via CD39 and CD73, and mediate immunosuppression via the adenosine and A2A pathways. Apoptosis in Treg cells is attributed to their weak NRF2-associated antioxidant system and high vulnerability to free oxygen species in the tumor microenvironment. Thus, the data support a model wherein tumor Treg cells sustain and amplify their suppressor capacity through inadvertent death via oxidative stress. This work highlights the oxidative pathway as a metabolic checkpoint that controls Treg cell behavior and affects the efficacy of therapeutics targeting cancer checkpoints." @default.
- W2765354611 created "2017-11-10" @default.
- W2765354611 creator A5005093063 @default.
- W2765354611 creator A5009953160 @default.
- W2765354611 creator A5020751352 @default.
- W2765354611 creator A5024842622 @default.
- W2765354611 creator A5028677580 @default.
- W2765354611 creator A5036533952 @default.
- W2765354611 creator A5046597133 @default.
- W2765354611 creator A5051068325 @default.
- W2765354611 creator A5054392992 @default.
- W2765354611 creator A5060035414 @default.
- W2765354611 creator A5075804518 @default.
- W2765354611 creator A5085494535 @default.
- W2765354611 creator A5086113297 @default.
- W2765354611 creator A5088147590 @default.
- W2765354611 date "2017-10-30" @default.
- W2765354611 modified "2023-10-17" @default.
- W2765354611 title "Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor" @default.
- W2765354611 cites W1530044612 @default.
- W2765354611 cites W1550301398 @default.
- W2765354611 cites W1561349380 @default.
- W2765354611 cites W161060649 @default.
- W2765354611 cites W1966768211 @default.
- W2765354611 cites W1971084572 @default.
- W2765354611 cites W1980780108 @default.
- W2765354611 cites W1990423632 @default.
- W2765354611 cites W2000799034 @default.
- W2765354611 cites W2001207281 @default.
- W2765354611 cites W2002726823 @default.
- W2765354611 cites W2004014851 @default.
- W2765354611 cites W2004708987 @default.
- W2765354611 cites W2030749349 @default.
- W2765354611 cites W2053353274 @default.
- W2765354611 cites W2056721231 @default.
- W2765354611 cites W2063261544 @default.
- W2765354611 cites W2063779547 @default.
- W2765354611 cites W2073025161 @default.
- W2765354611 cites W2073310925 @default.
- W2765354611 cites W2076537509 @default.
- W2765354611 cites W2082837925 @default.
- W2765354611 cites W2086834997 @default.
- W2765354611 cites W2097259163 @default.
- W2765354611 cites W2097811455 @default.
- W2765354611 cites W2098736083 @default.
- W2765354611 cites W2100039832 @default.
- W2765354611 cites W2103021272 @default.
- W2765354611 cites W2106190040 @default.
- W2765354611 cites W2120010406 @default.
- W2765354611 cites W2120644528 @default.
- W2765354611 cites W2125742175 @default.
- W2765354611 cites W2130410032 @default.
- W2765354611 cites W2134053452 @default.
- W2765354611 cites W2138163780 @default.
- W2765354611 cites W2146791037 @default.
- W2765354611 cites W2150678612 @default.
- W2765354611 cites W2151937278 @default.
- W2765354611 cites W2153389047 @default.
- W2765354611 cites W2160551785 @default.
- W2765354611 cites W2162873738 @default.
- W2765354611 cites W2169729679 @default.
- W2765354611 cites W2202401513 @default.
- W2765354611 cites W2292383635 @default.
- W2765354611 cites W2342880373 @default.
- W2765354611 cites W2344037260 @default.
- W2765354611 cites W2395626624 @default.
- W2765354611 cites W2510606169 @default.
- W2765354611 cites W2510836433 @default.
- W2765354611 cites W2519107733 @default.
- W2765354611 cites W2737785069 @default.
- W2765354611 cites W4239710358 @default.
- W2765354611 doi "https://doi.org/10.1038/ni.3868" @default.
- W2765354611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5770150" @default.
- W2765354611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29083399" @default.
- W2765354611 hasPublicationYear "2017" @default.
- W2765354611 type Work @default.
- W2765354611 sameAs 2765354611 @default.
- W2765354611 citedByCount "466" @default.
- W2765354611 countsByYear W27653546112017 @default.
- W2765354611 countsByYear W27653546112018 @default.
- W2765354611 countsByYear W27653546112019 @default.
- W2765354611 countsByYear W27653546112020 @default.
- W2765354611 countsByYear W27653546112021 @default.
- W2765354611 countsByYear W27653546112022 @default.
- W2765354611 countsByYear W27653546112023 @default.
- W2765354611 crossrefType "journal-article" @default.
- W2765354611 hasAuthorship W2765354611A5005093063 @default.
- W2765354611 hasAuthorship W2765354611A5009953160 @default.
- W2765354611 hasAuthorship W2765354611A5020751352 @default.
- W2765354611 hasAuthorship W2765354611A5024842622 @default.
- W2765354611 hasAuthorship W2765354611A5028677580 @default.
- W2765354611 hasAuthorship W2765354611A5036533952 @default.
- W2765354611 hasAuthorship W2765354611A5046597133 @default.
- W2765354611 hasAuthorship W2765354611A5051068325 @default.
- W2765354611 hasAuthorship W2765354611A5054392992 @default.
- W2765354611 hasAuthorship W2765354611A5060035414 @default.
- W2765354611 hasAuthorship W2765354611A5075804518 @default.
- W2765354611 hasAuthorship W2765354611A5085494535 @default.