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• W2765363984 abstract "Abstract The mechanism whereby anesthetics cause loss of consciousness (LOC) is poorly understood. Current theories suggest that impaired representation of information in cortico-thalamic networks contributes to LOC under anesthesia. We sought to determine whether such changes are present in auditory cortex using information theoretic analysis of multiunit responses in rats. We tested the effects of three agents with different molecular targets: isoflurane, which acts at multiple pre- and postsynaptic loci, propofol, which acts primarily on GABA A receptors, and dexmedetomidine, an α 2 adrenergic agonist. We reasoned that changes in the representation of sensory stimuli causative for LOC would be present regardless of the molecular target of the anesthetic. All three agents caused LOC, as assayed by the loss of righting reflex (LORR). We presented acoustic stimuli that varied across a wide range of temporal and spectral dynamics under control, sub-hypnotic (i.e. dose too low to cause LORR), just-hypnotic (a dose just sufficient to cause LORR) and recovery conditions. Changes in mutual information (MI) between the stimulus and spike responses under anesthesia diverged in two ways from predictions of a model in which stimulus representation is impaired upon LOC. First, the sign of changes in MI was agent-specific: MI increased under dexmedetomidine, while it decreased under isoflurane and propofol. Second, there was no consistent change in MI when transitioning from sub-hyptnotic to just-hypnotic doses: for none of the agents did MI decrease at the higher dose, and in some cases MI actually increased relative to the sub-hypnotic dose. Changes in MI under anesthesia were strongly correlated with changes in precision and reliability of spike timing, consistent with the importance of temporal stimulus features in driving auditory cortical activity. These data indicate that primary sensory cortex is not the locus for changes in information representation causative for LOC under anesthesia." @default.
• W2765363984 created "2017-11-10" @default.
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• W2765363984 date "2017-11-02" @default.
• W2765363984 modified "2023-10-18" @default.
• W2765363984 title "Evidence that loss of consciousness under anesthesia is not associated with impaired stimulus representation in auditory cortex" @default.
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• W2765363984 doi "https://doi.org/10.1101/213355" @default.
• W2765363984 hasPublicationYear "2017" @default.
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