Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765373097> ?p ?o ?g. }
- W2765373097 endingPage "F268" @default.
- W2765373097 startingPage "F260" @default.
- W2765373097 abstract "Our laboratory recently made the novel observation that 5-hydroxytryptamine 1F (5-HT 1F ) receptor activation induces mitochondrial biogenesis (MB), the production of new, functional mitochondria, in vitro and in vivo. We sought to determine the mechanism linking the 5-HT 1F receptor to MB in renal proximal tubule cells. Using LY344864 , a selective 5-HT 1F receptor agonist, we determined that the 5-HT 1F receptor is coupled to Gα i/o and induces MB through Gβγ-dependent activation of Akt, endothelial nitric oxide synthase (eNOS), cyclic guanosine-monophosphate (cGMP), protein kinase G (PKG), and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). We also report that the 5-HT 1F receptor signals through a second, Gβγ-dependent pathway that is linked by Akt phosphorylation of Raf. In contrast to the activated Akt pathway, Raf phosphorylation reduced extracellular signal regulated kinases (ERK1/2) and foxhead box O3a (FOXO3a) phosphorylation, suppressing an inhibitory MB pathway. These results demonstrate that the 5-HT 1F receptor regulates MB through Gβγ-dependent dual mechanisms that activate a stimulatory MB pathway, Akt/eNOS/cGMP/PKG/PGC-1α, while simultaneously repressing an inhibitory MB pathway, Raf/MEK/ERK/FOXO3a. Novel mechanisms of MB provide the foundation for new chemicals that induce MB to treat acute and chronic organ injuries." @default.
- W2765373097 created "2017-11-10" @default.
- W2765373097 creator A5004628839 @default.
- W2765373097 creator A5008078327 @default.
- W2765373097 creator A5014698231 @default.
- W2765373097 creator A5082611786 @default.
- W2765373097 date "2018-02-01" @default.
- W2765373097 modified "2023-10-12" @default.
- W2765373097 title "Identification of dual mechanisms mediating 5-hydroxytryptamine receptor 1F-induced mitochondrial biogenesis" @default.
- W2765373097 cites W1492607105 @default.
- W2765373097 cites W1589421810 @default.
- W2765373097 cites W1764308599 @default.
- W2765373097 cites W1910713930 @default.
- W2765373097 cites W1920523949 @default.
- W2765373097 cites W1971727526 @default.
- W2765373097 cites W1977116507 @default.
- W2765373097 cites W1977591229 @default.
- W2765373097 cites W1979632514 @default.
- W2765373097 cites W1983583299 @default.
- W2765373097 cites W1984621921 @default.
- W2765373097 cites W1985538065 @default.
- W2765373097 cites W1989369409 @default.
- W2765373097 cites W1990414934 @default.
- W2765373097 cites W1990839004 @default.
- W2765373097 cites W1996049651 @default.
- W2765373097 cites W1999086913 @default.
- W2765373097 cites W2008632158 @default.
- W2765373097 cites W2008776686 @default.
- W2765373097 cites W2014047570 @default.
- W2765373097 cites W2017292900 @default.
- W2765373097 cites W2025664869 @default.
- W2765373097 cites W2035593978 @default.
- W2765373097 cites W2035785328 @default.
- W2765373097 cites W2048466476 @default.
- W2765373097 cites W2048986390 @default.
- W2765373097 cites W2055222402 @default.
- W2765373097 cites W2055511156 @default.
- W2765373097 cites W2058278329 @default.
- W2765373097 cites W2066517990 @default.
- W2765373097 cites W2070290419 @default.
- W2765373097 cites W2081622555 @default.
- W2765373097 cites W2086714780 @default.
- W2765373097 cites W2087846936 @default.
- W2765373097 cites W2088086126 @default.
- W2765373097 cites W2095769092 @default.
- W2765373097 cites W2102246235 @default.
- W2765373097 cites W2105404724 @default.
- W2765373097 cites W2106701169 @default.
- W2765373097 cites W2106784014 @default.
- W2765373097 cites W2111800953 @default.
- W2765373097 cites W2116642215 @default.
- W2765373097 cites W2124105006 @default.
- W2765373097 cites W2127659234 @default.
- W2765373097 cites W2134141047 @default.
- W2765373097 cites W2135942966 @default.
- W2765373097 cites W2139129548 @default.
- W2765373097 cites W2145450729 @default.
- W2765373097 cites W2150874450 @default.
- W2765373097 cites W2156449116 @default.
- W2765373097 cites W2158375208 @default.
- W2765373097 cites W2167793478 @default.
- W2765373097 cites W2171256006 @default.
- W2765373097 cites W2180569405 @default.
- W2765373097 cites W2290885075 @default.
- W2765373097 cites W2414361303 @default.
- W2765373097 cites W2526267187 @default.
- W2765373097 cites W2552340576 @default.
- W2765373097 cites W2901937269 @default.
- W2765373097 cites W568373222 @default.
- W2765373097 doi "https://doi.org/10.1152/ajprenal.00324.2017" @default.
- W2765373097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5866450" @default.
- W2765373097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29046298" @default.
- W2765373097 hasPublicationYear "2018" @default.
- W2765373097 type Work @default.
- W2765373097 sameAs 2765373097 @default.
- W2765373097 citedByCount "16" @default.
- W2765373097 countsByYear W27653730972017 @default.
- W2765373097 countsByYear W27653730972018 @default.
- W2765373097 countsByYear W27653730972019 @default.
- W2765373097 countsByYear W27653730972020 @default.
- W2765373097 countsByYear W27653730972021 @default.
- W2765373097 countsByYear W27653730972022 @default.
- W2765373097 countsByYear W27653730972023 @default.
- W2765373097 crossrefType "journal-article" @default.
- W2765373097 hasAuthorship W2765373097A5004628839 @default.
- W2765373097 hasAuthorship W2765373097A5008078327 @default.
- W2765373097 hasAuthorship W2765373097A5014698231 @default.
- W2765373097 hasAuthorship W2765373097A5082611786 @default.
- W2765373097 hasBestOaLocation W27653730971 @default.
- W2765373097 hasConcept C11960822 @default.
- W2765373097 hasConcept C170493617 @default.
- W2765373097 hasConcept C184235292 @default.
- W2765373097 hasConcept C185592680 @default.
- W2765373097 hasConcept C2777229759 @default.
- W2765373097 hasConcept C28859421 @default.
- W2765373097 hasConcept C55493867 @default.
- W2765373097 hasConcept C57074206 @default.
- W2765373097 hasConcept C62478195 @default.