FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765387508> ?p ?o ?g. }

• W2765387508 abstract "mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1 and TIAR) that recognize AU-rich elements (AREs) at the 3' untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or the subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches." @default.
• W2765387508 created "2017-11-10" @default.
• W2765387508 creator A5022305364 @default.
• W2765387508 creator A5040759965 @default.
• W2765387508 creator A5048532719 @default.
• W2765387508 creator A5049125752 @default.
• W2765387508 creator A5067563831 @default.
• W2765387508 creator A5070776007 @default.
• W2765387508 creator A5073543584 @default.
• W2765387508 date "2017-10-23" @default.
• W2765387508 modified "2023-10-18" @default.
• W2765387508 title "RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate" @default.
• W2765387508 cites W1578727895 @default.
• W2765387508 cites W1582509777 @default.
• W2765387508 cites W1589201760 @default.
• W2765387508 cites W1790543114 @default.
• W2765387508 cites W1973268693 @default.
• W2765387508 cites W1974066524 @default.
• W2765387508 cites W1977182685 @default.
• W2765387508 cites W1978501832 @default.
• W2765387508 cites W1982925662 @default.
• W2765387508 cites W1984574291 @default.
• W2765387508 cites W1985023569 @default.
• W2765387508 cites W1986938385 @default.
• W2765387508 cites W1988097332 @default.
• W2765387508 cites W1989504358 @default.
• W2765387508 cites W1989549358 @default.
• W2765387508 cites W1991510039 @default.
• W2765387508 cites W1994712042 @default.
• W2765387508 cites W1996876030 @default.
• W2765387508 cites W1998163143 @default.
• W2765387508 cites W2001973462 @default.
• W2765387508 cites W2003287029 @default.
• W2765387508 cites W2005558505 @default.
• W2765387508 cites W2008008912 @default.
• W2765387508 cites W2016489736 @default.
• W2765387508 cites W2016776106 @default.
• W2765387508 cites W2018587522 @default.
• W2765387508 cites W2019563964 @default.
• W2765387508 cites W2020081155 @default.
• W2765387508 cites W2025296756 @default.
• W2765387508 cites W2029140175 @default.
• W2765387508 cites W2030180346 @default.
• W2765387508 cites W2030248691 @default.
• W2765387508 cites W2038413819 @default.
• W2765387508 cites W2043510207 @default.
• W2765387508 cites W2043774796 @default.
• W2765387508 cites W2045342567 @default.
• W2765387508 cites W2047241280 @default.
• W2765387508 cites W2048651813 @default.
• W2765387508 cites W2048849569 @default.
• W2765387508 cites W2050324319 @default.
• W2765387508 cites W2052128932 @default.
• W2765387508 cites W2053451907 @default.
• W2765387508 cites W2054574453 @default.
• W2765387508 cites W2060573836 @default.
• W2765387508 cites W2071897491 @default.
• W2765387508 cites W2072571326 @default.
• W2765387508 cites W2072622898 @default.
• W2765387508 cites W2073273460 @default.
• W2765387508 cites W2073427046 @default.
• W2765387508 cites W2076389002 @default.
• W2765387508 cites W2077310227 @default.
• W2765387508 cites W2079898750 @default.
• W2765387508 cites W2080505162 @default.
• W2765387508 cites W2082639157 @default.
• W2765387508 cites W2083123268 @default.
• W2765387508 cites W2086510997 @default.
• W2765387508 cites W2087744052 @default.
• W2765387508 cites W2090703970 @default.
• W2765387508 cites W2096259566 @default.
• W2765387508 cites W2098387574 @default.
• W2765387508 cites W2098775968 @default.
• W2765387508 cites W2102107106 @default.
• W2765387508 cites W2102606027 @default.
• W2765387508 cites W2104905071 @default.
• W2765387508 cites W2105186321 @default.
• W2765387508 cites W2105933042 @default.
• W2765387508 cites W2106154073 @default.
• W2765387508 cites W2108057660 @default.
• W2765387508 cites W2110315273 @default.
• W2765387508 cites W2111841684 @default.
• W2765387508 cites W2112015968 @default.
• W2765387508 cites W2127337265 @default.
• W2765387508 cites W2128132267 @default.
• W2765387508 cites W2129377911 @default.
• W2765387508 cites W2129649868 @default.
• W2765387508 cites W2130137363 @default.
• W2765387508 cites W2133508538 @default.
• W2765387508 cites W2134456488 @default.
• W2765387508 cites W2135070076 @default.
• W2765387508 cites W2135679340 @default.
• W2765387508 cites W2140084664 @default.
• W2765387508 cites W2142664123 @default.
• W2765387508 cites W2144398839 @default.
• W2765387508 cites W2144471733 @default.
• W2765387508 cites W2149541702 @default.
• W2765387508 cites W2152432732 @default.
• W2765387508 cites W2152444475 @default.
• W2765387508 cites W2154122744 @default.

• next