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- W2765397291 abstract "Alzheimer's disease (AD) related pathological changes such as amyloid beta deposition and hyperphosphorylated tau develop insidiously more than 20 years before onset of cognitive decline. It is emphasized that early therapy at preclinical stage. Development of amyloid PET and tau PET could detect preclinical AD pathology, but are not useful for usual screening. More useful preclinical AD biomarkers are exactly expected. 277 cognitively normal elderly subjects with informed consent were recruited. All subjects are clinically followed up using by undertake Mini Mental State Examination (MMSE), MRI including VSRAD showing severity of medial temporal atrophy (MTA) as Z-score, and Magnetic Resonance Spectroscopy (1H MRS) at the posterior cingulate cortex (PCC) for five years from baseline. The cerebrospinal fluid (CSF) was obtained from all subjects at baseline for measuring CSF amyloid Aβ42 and CSF P-tau by Enzyme-Linked ImmunoSorbent Assay. At baseline, MMSE score of 277 subjects was 28.9±1.7 without brain atrophy: Z-score of MTA was 1.0±0.4. Of 277 subjects, N-acetylaspartate (NAA) / Myo-inositol (MI) of PCC by 1H MRS showed that 171 was 1.8±0.1(normal range); 99 was 1.7±0.2(moderately decreased) and 7 was 1.5±0.2(significantly decreased). Of 277 subjects, CSF Aβ42 levels revealed that 49 was 962.3±274.5(normal range); 65 was 676.6±334.6 (decreased) and 7 was 516.7±124.8 pg/ml (mildly decreased). CSF P -tau levels revealed that 56 was 38.5±14.4 (normal range); 65 was 72.4±34.9 (increased) at baseline. After 5 years from baseline, 164 of 171 remains cognitively normal whose NAA/MI is 1.9±0.2 (1.8±0.1 at baseline); 99 converted MCI whose NAA/MI is 1.75±0.2 (1.7±0.2 at baseline); 10 become early Parkinson's disease (PD) whose NAA/MI at PCC is 1.9±0.2 (1.8±0.1 at baseline) and 4 developed Dementia with Lewy bodies (DLB) whose NAA/MI is 1.4±0.2(1.5±0.2 at baseline). Moreover, the 65 of 277 subjects who showed decreased CSF Aβ42 levels /increased CSF P-tau levels at baseline mostly developed to MCI 5 years later." @default.
- W2765397291 created "2017-11-10" @default.
- W2765397291 creator A5002371712 @default.
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- W2765397291 date "2017-07-01" @default.
- W2765397291 modified "2023-09-27" @default.
- W2765397291 title "[P3-394]: ABNORMALITIES OF MRS OF THE POSTERIOR CINGULATE CORTEX MAY PRECEDE ONSET OF MCI DUE TO ALZHEIMER's DISEASE: FIVE YEARS’ FOLLOW UP STUDY OF 277 COGNITIVELY NORMAL ELDERLY SUBJECTS" @default.
- W2765397291 doi "https://doi.org/10.1016/j.jalz.2017.06.1610" @default.
- W2765397291 hasPublicationYear "2017" @default.
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