Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765409306> ?p ?o ?g. }
- W2765409306 abstract "Stroke is a major cause of mortality and disability worldwide. Stroke is a frequent and severe neurovascular disorder. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, prevention and treatment of stroke are crucial issues in humans. High mobility group box 1 (HMGB1) is non-histone nuclear protein that is currently one of the crucial proinflammatory alarmins in ischemic stroke (IS). It is instantly released from necrotic cells in the ischemic core and activates an early inflammatory response. HMGB1 may signal via its putative receptors, such as receptor for advanced glycation end products (RAGE), toll-like receptors (TLRs) as well as matrix metalloproteinase (MMP) enzymes during IS. These receptors are expressed in brain cells. Additionally, brain-released HMGB1 can be redox modified in the circulation and activate peripheral immune cells. The role of HMGB1 may be more complex. HMGB1 possesses beneficial actions, such as endothelial activation, enhancement of neurite outgrowth, and neuronal survival. HMGB1 may also provide a novel link for brain-immune communication leading to post-stroke immunomodulation. Therefore, HMGB1 is new promising therapeutic intervention aimed at promoting neurovascular repair and remodeling after stroke. In this review, we look at the mechanisms of secretion of HMGB1, the role of receptors, MMP enzymes, hypoglycemia, atherosclerosis, edema, angiogenesis as well as neuroimmunological reactions and post-ischemic brain recovery in IS. We also outline therapeutic roles of HMGB1 in IS." @default.
- W2765409306 created "2017-11-10" @default.
- W2765409306 creator A5013958974 @default.
- W2765409306 creator A5043109704 @default.
- W2765409306 creator A5044241067 @default.
- W2765409306 creator A5050266837 @default.
- W2765409306 date "2017-12-05" @default.
- W2765409306 modified "2023-10-14" @default.
- W2765409306 title "Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke" @default.
- W2765409306 cites W1484383992 @default.
- W2765409306 cites W1495656315 @default.
- W2765409306 cites W1497375745 @default.
- W2765409306 cites W1511842456 @default.
- W2765409306 cites W1514838725 @default.
- W2765409306 cites W1541957757 @default.
- W2765409306 cites W1553707188 @default.
- W2765409306 cites W1597543466 @default.
- W2765409306 cites W1620345881 @default.
- W2765409306 cites W1672954108 @default.
- W2765409306 cites W173128540 @default.
- W2765409306 cites W1847797033 @default.
- W2765409306 cites W1943065335 @default.
- W2765409306 cites W1968026156 @default.
- W2765409306 cites W1973338533 @default.
- W2765409306 cites W1975898995 @default.
- W2765409306 cites W1976010325 @default.
- W2765409306 cites W1977962646 @default.
- W2765409306 cites W1978718183 @default.
- W2765409306 cites W1980044612 @default.
- W2765409306 cites W1985455477 @default.
- W2765409306 cites W198550484 @default.
- W2765409306 cites W1985921128 @default.
- W2765409306 cites W1987278634 @default.
- W2765409306 cites W1988100193 @default.
- W2765409306 cites W1989321502 @default.
- W2765409306 cites W1989591516 @default.
- W2765409306 cites W1996024251 @default.
- W2765409306 cites W1996558604 @default.
- W2765409306 cites W1996906345 @default.
- W2765409306 cites W1997951995 @default.
- W2765409306 cites W1998557118 @default.
- W2765409306 cites W1998932530 @default.
- W2765409306 cites W1999354118 @default.
- W2765409306 cites W2000104703 @default.
- W2765409306 cites W2002351008 @default.
- W2765409306 cites W2004149652 @default.
- W2765409306 cites W2004264059 @default.
- W2765409306 cites W2004266769 @default.
- W2765409306 cites W2004437604 @default.
- W2765409306 cites W2004831480 @default.
- W2765409306 cites W2005669608 @default.
- W2765409306 cites W2005675003 @default.
- W2765409306 cites W2008721781 @default.
- W2765409306 cites W2009881447 @default.
- W2765409306 cites W2012681341 @default.
- W2765409306 cites W2013100814 @default.
- W2765409306 cites W2016575029 @default.
- W2765409306 cites W2017678782 @default.
- W2765409306 cites W2018590829 @default.
- W2765409306 cites W2021867771 @default.
- W2765409306 cites W2022689945 @default.
- W2765409306 cites W2022740116 @default.
- W2765409306 cites W2023250693 @default.
- W2765409306 cites W2023749167 @default.
- W2765409306 cites W2024570136 @default.
- W2765409306 cites W2028294482 @default.
- W2765409306 cites W2031809301 @default.
- W2765409306 cites W2032102818 @default.
- W2765409306 cites W2034882426 @default.
- W2765409306 cites W2035474969 @default.
- W2765409306 cites W2036168448 @default.
- W2765409306 cites W2039784479 @default.
- W2765409306 cites W2041851050 @default.
- W2765409306 cites W2042795861 @default.
- W2765409306 cites W2045098547 @default.
- W2765409306 cites W2047376205 @default.
- W2765409306 cites W2048047884 @default.
- W2765409306 cites W2048350854 @default.
- W2765409306 cites W2048903425 @default.
- W2765409306 cites W2052322755 @default.
- W2765409306 cites W2056258976 @default.
- W2765409306 cites W2059217150 @default.
- W2765409306 cites W2062445975 @default.
- W2765409306 cites W2062993799 @default.
- W2765409306 cites W2065947741 @default.
- W2765409306 cites W2066158538 @default.
- W2765409306 cites W2068517470 @default.
- W2765409306 cites W2070800689 @default.
- W2765409306 cites W2070940233 @default.
- W2765409306 cites W2071932055 @default.
- W2765409306 cites W2074453941 @default.
- W2765409306 cites W2077017483 @default.
- W2765409306 cites W2077865453 @default.
- W2765409306 cites W2079148500 @default.
- W2765409306 cites W2082273088 @default.
- W2765409306 cites W2082470753 @default.
- W2765409306 cites W2084430660 @default.
- W2765409306 cites W2084498863 @default.
- W2765409306 cites W2084623259 @default.
- W2765409306 cites W2090213064 @default.