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- W2765430910 abstract "Renal impairment commonly occurs in patients with liver disease and particularly cirrhosis. Acute kidney injury encompasses a diverse range of pathologies that exist on the spectrum of reversible with minimal structural damages (e.g., prerenal azotemia) to irreversible with severe and permanent structural damage (e.g., a severe form of acute tubular necrosis). Hepatorenal syndrome is increasingly recognized as a heterogeneous group of disorders that exist on this spectrum. It can be precipitated by various events that worsen arterial vasodilatation, intravascular volume depletion, or systemic inflammation. The best available medical treatment is vasoconstrictor therapy in conjunction with albumin, but even then response rate is modest. Failure to respond to treatment bodes poor prognosis. Liver transplantation is the definitive treatment; even then, long-term sequelae from renal dysfunction can result. The best treatment for cirrhotic patients at risk of renal impairment is therefore still prevention (i.e., avoidance of precipitating factors)." @default.
- W2765430910 created "2017-11-10" @default.
- W2765430910 creator A5002878937 @default.
- W2765430910 creator A5021646906 @default.
- W2765430910 date "2017-10-23" @default.
- W2765430910 modified "2023-10-14" @default.
- W2765430910 title "Renal Complications of Liver Disease and the Hepatorenal Syndrome" @default.
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- W2765430910 doi "https://doi.org/10.1002/9781119251316.ch13" @default.
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