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- W2765432042 abstract "The clinical relevance of the association between venous thromboembolism (VTE) and cancer is well documented. VTE is one of the leading causes of death in cancer patients. It would be an advantage to have knowledge on predictive parameters for the development of thrombosis and to be able to select cancer patients individually according to their risk profile. An elevated platelet count is associated with an increased risk of VTE in cancer patients. The biomarkers including D-dimer have been identified and used to extend the existing risk stratification. The stand-alone D-dimer testing at a positivity threshold cannot safely rule out VTE in patients with active cancer. Treatment of VTE in cancer patients is complicated due to a high rate of recurrent VTE in addition to a higher risk of bleeding during anticoagulation therapy. Current guidelines recommend low-molecular-weight heparin (LMWH) monotherapy over vitamin K antagonist (VKA) for the treatment of cancer-associated VTE. However, recent clinical study could not show superior efficacy of LMWH over VKA in preventing VTE recurrence or overall mortality. The direct oral anticoagulants (DOACs) may be an effective treatment for VTE in cancer patients, although the risk reduction for recurrent VTE with the DOACs compared to LMWH has not been well assessed. The recent open label trials showed that edoxaban is effective as VKA for the treatment of VTE without relevant bleeding in patients with cancer. Physicians should frequently re-evaluate the risk-benefit ratio of ongoing anticoagulant therapy in individual patients, in views of the overall clinical condition of the patient including their quality of life and life expectancy. In this symposium, we highlight the pathophysiology of cancer-associated thrombosis and management of VTE." @default.
- W2765432042 created "2017-11-10" @default.
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- W2765432042 date "2017-10-01" @default.
- W2765432042 modified "2023-09-30" @default.
- W2765432042 title "Management of venous thromboembolism in cancer patients" @default.
- W2765432042 doi "https://doi.org/10.1093/annonc/mdx575.004" @default.
- W2765432042 hasPublicationYear "2017" @default.
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