FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765432582> ?p ?o ?g. }

• W2765432582 endingPage "1205" @default.
• W2765432582 startingPage "1194" @default.
• W2765432582 abstract "BackgroundGeneral anaesthesia leads to atelectasis, reduced end-expiratory lung volume (EELV), and diminished arterial oxygenation in obese patients. We hypothesized that a combination of a recruitment manoeuvre (RM) and individualized positive end-expiratory pressure (PEEP) can avoid these effects.MethodsPatients with a BMI ≥35 kg m−2 undergoing elective laparoscopic surgery were randomly allocated to mechanical ventilation with a tidal volume of 8 ml kg−1 predicted body weight and (i) an RM followed by individualized PEEP titrated using electrical impedance tomography (PEEPIND) or (ii) no RM and PEEP of 5 cm H2O (PEEP5). Gas exchange, regional ventilation distribution, and EELV (multiple breath nitrogen washout method) were determined before, during, and after anaesthesia. The primary end point was the ratio of arterial partial pressure of oxygen to inspiratory oxygen fraction (PaO2/FiO2).ResultsFor PEEPIND (n=25) and PEEP5 (n=25) arms together, PaO2/FiO2 and EELV decreased by 15 kPa [95% confidence interval (CI) 11–20 kPa, P<0.001] and 1.2 litres (95% CI 0.9–1.6 litres, P<0.001), respectively, after intubation. Mean (sd) PEEPIND was 18.5 (5.6) cm H2O. In the PEEPIND arm, PaO2/FiO2 before extubation was 23 kPa higher (95% CI 16–29 kPa; P<0.001), EELV was 1.8 litres larger (95% CI 1.5–2.2 litres; P<0.001), driving pressure was 6.7 cm H2O lower (95% CI 5.4–7.9 cm H2O; P<0.001), and regional ventilation was more equally distributed than for PEEP5. After extubation, however, these differences between the arms vanished.ConclusionsIn obese patients, an RM and higher PEEPIND restored EELV, regional ventilation distribution, and oxygenation during anaesthesia, but these differences did not persist after extubation. Therefore, lung protection strategies should include the postoperative period.Clinical trial registrationGerman clinical trials register DRKS00004199, www.who.int/ictrp/network/drks2/en/." @default.
• W2765432582 created "2017-11-10" @default.
• W2765432582 creator A5016372808 @default.
• W2765432582 creator A5018545052 @default.
• W2765432582 creator A5021398195 @default.
• W2765432582 creator A5023543755 @default.
• W2765432582 creator A5031983636 @default.
• W2765432582 creator A5040941510 @default.
• W2765432582 creator A5042107059 @default.
• W2765432582 creator A5042716628 @default.
• W2765432582 creator A5055130996 @default.
• W2765432582 creator A5057718075 @default.
• W2765432582 creator A5060214707 @default.
• W2765432582 creator A5071291978 @default.
• W2765432582 creator A5089731984 @default.
• W2765432582 date "2017-12-01" @default.
• W2765432582 modified "2023-10-17" @default.
• W2765432582 title "Individualized positive end-expiratory pressure in obese patients during general anaesthesia: a randomized controlled clinical trial using electrical impedance tomography" @default.
• W2765432582 cites W1534353916 @default.
• W2765432582 cites W1820839252 @default.
• W2765432582 cites W1940579175 @default.
• W2765432582 cites W1973121659 @default.
• W2765432582 cites W1990985236 @default.
• W2765432582 cites W2000366267 @default.
• W2765432582 cites W2010100300 @default.
• W2765432582 cites W2019485790 @default.
• W2765432582 cites W2026450237 @default.
• W2765432582 cites W2059248210 @default.
• W2765432582 cites W2067361424 @default.
• W2765432582 cites W2067452996 @default.
• W2765432582 cites W2072581871 @default.
• W2765432582 cites W2074691764 @default.
• W2765432582 cites W2076991415 @default.
• W2765432582 cites W2080307279 @default.
• W2765432582 cites W2081544425 @default.
• W2765432582 cites W2085619115 @default.
• W2765432582 cites W2105999224 @default.
• W2765432582 cites W2124551855 @default.
• W2765432582 cites W2127095996 @default.
• W2765432582 cites W2130318815 @default.
• W2765432582 cites W2133245655 @default.
• W2765432582 cites W2133957981 @default.
• W2765432582 cites W2134790525 @default.
• W2765432582 cites W2142302740 @default.
• W2765432582 cites W2145605209 @default.
• W2765432582 cites W2147769475 @default.
• W2765432582 cites W2151898076 @default.
• W2765432582 cites W2162001089 @default.
• W2765432582 cites W2162002744 @default.
• W2765432582 cites W2167431840 @default.
• W2765432582 cites W2286228001 @default.
• W2765432582 cites W2291900475 @default.
• W2765432582 cites W2316124239 @default.
• W2765432582 cites W2334749998 @default.
• W2765432582 cites W2337057834 @default.
• W2765432582 cites W2347190905 @default.
• W2765432582 cites W2390392556 @default.
• W2765432582 cites W2397296858 @default.
• W2765432582 cites W2515848350 @default.
• W2765432582 cites W2994597783 @default.
• W2765432582 cites W42316583 @default.
• W2765432582 cites W4233094824 @default.
• W2765432582 cites W81990000 @default.
• W2765432582 doi "https://doi.org/10.1093/bja/aex192" @default.
• W2765432582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29045567" @default.
• W2765432582 hasPublicationYear "2017" @default.
• W2765432582 type Work @default.
• W2765432582 sameAs 2765432582 @default.
• W2765432582 citedByCount "138" @default.
• W2765432582 countsByYear W27654325822018 @default.
• W2765432582 countsByYear W27654325822019 @default.
• W2765432582 countsByYear W27654325822020 @default.
• W2765432582 countsByYear W27654325822021 @default.
• W2765432582 countsByYear W27654325822022 @default.
• W2765432582 countsByYear W27654325822023 @default.
• W2765432582 crossrefType "journal-article" @default.
• W2765432582 hasAuthorship W2765432582A5016372808 @default.
• W2765432582 hasAuthorship W2765432582A5018545052 @default.
• W2765432582 hasAuthorship W2765432582A5021398195 @default.
• W2765432582 hasAuthorship W2765432582A5023543755 @default.
• W2765432582 hasAuthorship W2765432582A5031983636 @default.
• W2765432582 hasAuthorship W2765432582A5040941510 @default.
• W2765432582 hasAuthorship W2765432582A5042107059 @default.
• W2765432582 hasAuthorship W2765432582A5042716628 @default.
• W2765432582 hasAuthorship W2765432582A5055130996 @default.
• W2765432582 hasAuthorship W2765432582A5057718075 @default.
• W2765432582 hasAuthorship W2765432582A5060214707 @default.
• W2765432582 hasAuthorship W2765432582A5071291978 @default.
• W2765432582 hasAuthorship W2765432582A5089731984 @default.
• W2765432582 hasBestOaLocation W27654325821 @default.
• W2765432582 hasConcept C126322002 @default.
• W2765432582 hasConcept C127413603 @default.
• W2765432582 hasConcept C200457457 @default.
• W2765432582 hasConcept C27101514 @default.
• W2765432582 hasConcept C2776983577 @default.
• W2765432582 hasConcept C2777080012 @default.
• W2765432582 hasConcept C2777257755 @default.
• W2765432582 hasConcept C2777714996 @default.

• next