Matches in SemOpenAlex for { <https://semopenalex.org/work/W2765434473> ?p ?o ?g. }
- W2765434473 endingPage "a028449" @default.
- W2765434473 startingPage "a028449" @default.
- W2765434473 abstract "Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their sharing the common cytokine receptor γ chain (γc), which was originally discovered as the third receptor component of the IL-2 receptor, IL-2Rγ. The IL2RG gene is located on the X chromosome and is mutated in humans with X-linked severe combined immunodeficiency (XSCID). The breadth of the defects in XSCID could not be explained solely by defects in IL-2 signaling, and it is now clear that γc is a shared receptor component of the six cytokines noted above, making XSCID a disease of defective cytokine signaling. Janus kinase (JAK)3 associates with γc, and JAK3-deficient SCID phenocopies XSCID, findings that served to stimulate the development of JAK3 inhibitors as immunosuppressants. γc family cytokines collectively control broad aspects of lymphocyte development, growth, differentiation, and survival, and these cytokines are clinically important, related to allergic and autoimmune diseases and cancer as well as immunodeficiency. In this review, we discuss the actions of these cytokines, their critical biological roles and signaling pathways, focusing mainly on JAK/STAT (signal transducers and activators of transcription) signaling, and how this information is now being used in clinical therapeutic efforts." @default.
- W2765434473 created "2017-11-10" @default.
- W2765434473 creator A5012950291 @default.
- W2765434473 creator A5045690655 @default.
- W2765434473 date "2017-10-16" @default.
- W2765434473 modified "2023-10-16" @default.
- W2765434473 title "The Common Cytokine Receptor γ Chain Family of Cytokines" @default.
- W2765434473 cites W103687069 @default.
- W2765434473 cites W1486722793 @default.
- W2765434473 cites W1487210663 @default.
- W2765434473 cites W1498121841 @default.
- W2765434473 cites W1509163238 @default.
- W2765434473 cites W1516581843 @default.
- W2765434473 cites W1518759830 @default.
- W2765434473 cites W1532660854 @default.
- W2765434473 cites W1537534922 @default.
- W2765434473 cites W1555756643 @default.
- W2765434473 cites W1557599456 @default.
- W2765434473 cites W1558665965 @default.
- W2765434473 cites W1563775926 @default.
- W2765434473 cites W1564318084 @default.
- W2765434473 cites W1566445646 @default.
- W2765434473 cites W1567420244 @default.
- W2765434473 cites W1567604499 @default.
- W2765434473 cites W1575585006 @default.
- W2765434473 cites W1601504908 @default.
- W2765434473 cites W1673999527 @default.
- W2765434473 cites W1716267160 @default.
- W2765434473 cites W174236543 @default.
- W2765434473 cites W1758151596 @default.
- W2765434473 cites W1759409403 @default.
- W2765434473 cites W1763873242 @default.
- W2765434473 cites W1766130370 @default.
- W2765434473 cites W1797616819 @default.
- W2765434473 cites W1878828051 @default.
- W2765434473 cites W1882823390 @default.
- W2765434473 cites W1887331866 @default.
- W2765434473 cites W1893843472 @default.
- W2765434473 cites W1925756130 @default.
- W2765434473 cites W1939229836 @default.
- W2765434473 cites W1946393286 @default.
- W2765434473 cites W1946410206 @default.
- W2765434473 cites W1946955186 @default.
- W2765434473 cites W1947563713 @default.
- W2765434473 cites W1955441978 @default.
- W2765434473 cites W1962193832 @default.
- W2765434473 cites W1963232095 @default.
- W2765434473 cites W1964077677 @default.
- W2765434473 cites W1964973658 @default.
- W2765434473 cites W1965207154 @default.
- W2765434473 cites W1967112185 @default.
- W2765434473 cites W1968362887 @default.
- W2765434473 cites W1970474351 @default.
- W2765434473 cites W1970728276 @default.
- W2765434473 cites W1970854602 @default.
- W2765434473 cites W1971500432 @default.
- W2765434473 cites W1971992050 @default.
- W2765434473 cites W1972044265 @default.
- W2765434473 cites W1972254316 @default.
- W2765434473 cites W1973274031 @default.
- W2765434473 cites W1973548013 @default.
- W2765434473 cites W1974313653 @default.
- W2765434473 cites W1974842026 @default.
- W2765434473 cites W1975047479 @default.
- W2765434473 cites W1976355501 @default.
- W2765434473 cites W1977701102 @default.
- W2765434473 cites W1977715526 @default.
- W2765434473 cites W1977812814 @default.
- W2765434473 cites W1979026253 @default.
- W2765434473 cites W1981365528 @default.
- W2765434473 cites W1981597823 @default.
- W2765434473 cites W1982051091 @default.
- W2765434473 cites W1982696151 @default.
- W2765434473 cites W1982832618 @default.
- W2765434473 cites W1985577573 @default.
- W2765434473 cites W1986114734 @default.
- W2765434473 cites W1986763765 @default.
- W2765434473 cites W1986924748 @default.
- W2765434473 cites W1987076250 @default.
- W2765434473 cites W1988957385 @default.
- W2765434473 cites W1990233086 @default.
- W2765434473 cites W1990555844 @default.
- W2765434473 cites W1991018824 @default.
- W2765434473 cites W1991365762 @default.
- W2765434473 cites W1993426597 @default.
- W2765434473 cites W1993738044 @default.
- W2765434473 cites W1995297089 @default.
- W2765434473 cites W1996481500 @default.
- W2765434473 cites W1996642272 @default.
- W2765434473 cites W1997196319 @default.
- W2765434473 cites W1997241837 @default.
- W2765434473 cites W1997531619 @default.
- W2765434473 cites W1997883590 @default.
- W2765434473 cites W1999339423 @default.
- W2765434473 cites W1999495896 @default.
- W2765434473 cites W1999502549 @default.
- W2765434473 cites W2000208875 @default.
- W2765434473 cites W2000595280 @default.