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• W2765440581 abstract "Recently, several large-scale studies employed task-based functional magnetic resonance imaging (fMRI) to map brain activity in a general population. These population studies are not motived by one single hypothesis, but acquire fMRI data in the context of cognitive functions, lifestyle, health and biomarkers. Yet, most conventional task paradigms are optimized for a single question and are unsuitable for population imaging under high time-pressure. Here, we propose a highly efficient task-paradigm for mapping multisensory and memory-related fMRI activity (<10 min). Mixed with rest blocks, participants hear sounds (vocal/environmental) and observe images (faces/scenes), either singular or in parallel. The use of two parallel modalities (auditory/visual) allows contrasts for sensory-specific and sensory-unspecific brain activity. Secondly, a mixed design allows for contrasts of sustained and transient activity [1]. Thirdly, a subsequent recognition test allows for contrasts between remembered versus forgotten items, known as encoding success activity (ESA). Pilot data in 60 participants (mean age 24.2 years, 36 female) showed excellent recognition memory (d' = 1.19, SE = 0.05). In the auditory and visual cortex, we found sensory-specific ESA. In both sensory regions, positive ESA (remembered > forgotten) was driven by transient activations that coincided with sustained activity. In the hippocampus and default-network, we found sensory-unspecific ESA. In the hippocampus, positive ESA was driven by transient deactivations that coincided with sustained activity. In the default-network, negative ESA (forgotten > remembered) was driven by transient activations that coincided with sustained deactivations. These results demonstrate the feasibility to map multisensory and memory-related fMRI activity in a large-scale population study. Our findings also expose some issues regarding the ambiguity of the fMRI baseline [2]. Within our mixed design, transient ESA (remembered vs. forgotten) was relatively independent from sustained activity (task vs. rest). Thus, future studies can use our paradigm to clarify the influences of age and Alzheimer's pathology on both sustained and transient activity. [1] Visscher KM, et al. Mixed blocked/event-related designs separate transient and sustained activity in fMRI. NeuroImage 2003;19:1694–708 [2] Stark CE, Squire LR. When zero is not zero: the problem of ambiguous baseline conditions in fMRI. PNAS, 2001;98:12760–6." @default.
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• W2765440581 date "2017-07-01" @default.
• W2765440581 modified "2023-10-16" @default.
• W2765440581 title "[P3-334]: A PARALLEL MIXED DESIGN FOR MAPPING MULTISENSORY AND MEMORY-RELATED FMRI ACTIVITY IN A POPULATION STUDY" @default.
• W2765440581 doi "https://doi.org/10.1016/j.jalz.2017.06.1549" @default.
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