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- W2765456495 abstract "Card9 is a central signaling adaptor of the innate immune system that is engaged by different pattern recognition receptors to mediate inflammatory responses. Best studied is the role of Card9 in Syk-coupled C-type lectin receptor (CLR)-induced NF-κB activation. We now identified the Vav family of proteins as signaling hubs for CLR-induced inflammatory responses, and also discovered a CLR-Card9 signaling pathway regulating type I interferon production. In addition, we defined a non-redundant DNA recognition pathway for inflammation involving a direct interaction between the DNA-binding protein Rad50 and Card9." @default.
- W2765456495 created "2017-11-10" @default.
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- W2765456495 date "2017-01-01" @default.
- W2765456495 modified "2023-09-23" @default.
- W2765456495 title "Analysis of Card9 signaling in innate immunity" @default.
- W2765456495 hasPublicationYear "2017" @default.
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