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- W2765456599 endingPage "19" @default.
- W2765456599 startingPage "1" @default.
- W2765456599 abstract "Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors. In parallel, many neuroprotective substances have been tested for their efficacy and safety in hindering the negative effects that lead to RGC death. New formulations of these compounds, also suitable for chronic oral administration, are likely to be used in clinical practice in the future along with conventional therapies, in order to control the progression of the visual impairment due to primary open-angle glaucoma (POAG). This review illustrates some of these old and new promising agents for the adjuvant treatment of POAG, with particular emphasis on forskolin and melatonin." @default.
- W2765456599 created "2017-11-10" @default.
- W2765456599 creator A5013735073 @default.
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- W2765456599 creator A5067860653 @default.
- W2765456599 creator A5091254685 @default.
- W2765456599 date "2017-01-01" @default.
- W2765456599 modified "2023-10-18" @default.
- W2765456599 title "Neuroprotection in Glaucoma: Old and New Promising Treatments" @default.
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